An Efficient and Selective Pd-catalyzed Dehalogenation Reaction

Catalytic hydrogenative dechlorination reaction for efficient synthesis of a key intermediate of SDHI fungicides under continuous-flow conditions

“…7 based on previous reports. 15 The surface Pd 0 species I of the activated catalyst would insert into a C–Cl bond of CDFMMP 5 to give Pd 2+ intermediate II , and subsequently transform to intermediate III by salt metathesis, which has more nucleophilic acetate anions than intermediate II . A surface hydride species on a Pd particle would move to the reaction centre and give Pd hydride intermediate IV with liberation of AcOH.…”

In Situ Generation of Pd–Pt Core–Shell Nanoparticles on Reduced Graphene Oxide (Pd@Pt/rGO) Using Microwaves: Applications in Dehalogenation Reactions and Reduction of Olefins

“…In organic synthesis, catalytic dehalogenation reaction offers vast applicability, especially for the exploration of complex structures. , In most cases, however, such dehalogenation procedures were carried out by commercial Pd–C with molecular hydrogen and often require additional base for activation. ,, In contrast, our current approach provides an opportunity to utilize the catalytic system in the absence of molecular hydrogen or an external inorganic base.…”

Enzymatic Synthesis of Optically Active Lactones via Asymmetric Bioreduction using Ene‐Reductases from the Old Yellow Enzyme Family

“…Similarly, the absolute configurations of 6a and 6b were determined via kinetic resolution catalyzed by lipases according to a published protocol 24. For 7a , palladium‐catalyzed dehalogenation was employed to convert enantioenriched substrate 7a (recovered from enzymatic reaction with OPR3) to 7c with retention of configuration 25. The absolute configuration of 7c was then determined by comparison with authentic reference material obtained by palladium‐catalyzed allylic substitution of ( R )‐ 6a to ( R )‐ 7c (see the Experimental Section) 26.…”