An Efficient and Versatile Method for Synthesis of 1,4-Dihydropyridines at Mild Reaction Conditions

Abstract

Abstarct: A simple, efficient, versatile and convenient Hantzsch method for synthesis of 1,4-dihydropyridines using ethylacetoacetate, ammonium acetate and substituted arylaldehydes in the presence of tetrabutylammonium hydrogen sulfate (TBAHS) have been reported. Among the popular reported heterogenous solid catalysts, TBAHS has gained high popularity in organic synthesis due to its selectivity, inertness and thermal stability. The method offers advantages such as better yields, short reaction times, a simple work-up procedure, easy isolation of catalyst and reusability of catalyst for several runs.