An efficient approach for the enzyme-enhanced extraction of camptothecin and 10-hydroxycamptothecin from the samara of Camptotheca acuminata using an ionic liquid solution

Theoretical study on the solvation mechanism of camptothecin in ionic liquids

“…The complete explanations and calculation technique of the interaction energy between CPT and the cation–anion pair or a single ion of ILs are described in the ESI †Table 5. indicates that the Coulombic contribution between CPT and ILs correlates well with the solubility data obtained from the experiment and the reported experimental extraction results, 9,10,13 except for the [TsO] − anion system, where the vdW contribution plays a substantial role. These results manifest that the structures of different anions have different solvation mechanisms for CPT.…”

“…[4][5][6] Numerous authors have devoted their attention to the determination of the solubility of APIs in ILs as the foundation for the design of IL-based separation and purification processes. [7][8][9][10][11][12][13][14][15][16][17][18][19] Paluch et al 15 used [Bmim] + based ILs as solvents for the dissolution of the pharmaceutical compound lidocaine, which confirmed that the presence of a hydrogen bond (HB) between the lidocaine and anion of ILs greatly enhanced the solubility of lidocaine relative to water and VOSs. Wu et al 14 demonstrated that a novel extracting system based on the use of ILs is more attractive than the VOS-based extraction methods, and it was applied to determine tanshinones in the Chinese herbal medicine Salvia miltiorrhiza bunge.…”

“…Ma et al 13 studied the performance of various ILs with different cations and anions to develop an effective, rapid, and environmentally friendly extraction method of camptothecin (CPT) and 10-hydroxycamptothecin from Camptotheca acuminata Samara with an IL-aqueous solution ultrasonic-assisted extraction approach. Cui et al 9 tested the performance of several ILs with imidazolium-based cations ([C 2 mim] + , [C 4 mim] + , [C 6 mim] + , [C 8 mim] + , [C 10 mim] + ) and anions ([Br] − , [Cl] − , [OAc] − , [HsO 4 ] − , and [NO 3 ] − ) for drug extraction and proposed an enzyme-enhanced extraction technique using an IL solution. Wang et al 10 investigated ten different imidazolium-based ILs to select the optimal solvent in the extraction of CPT.…”

Mono N-Alkylated DABCO-Based Ionic Liquids and Their Application as Latent Curing Agents for Epoxy Resins

“…A very low level of volatility, an ionic structure in the liquid state below 100 °C, and a great variety of combinations of cations and anions are just some of them . In addition to the common features that allow these compounds to be called ionic liquids, they have various specific properties which determine their applications, for example, in electrochemistry, , as catalysts, , or as unique solvents in chemical reactions or for dissolution of biomass, for example, cellulose or lignin. , On the other hand, ILs can successfully increase the efficiency of enzymes such as β-galactosidase, enable the immobilization of enzymes on cellulose carriers or finally, can be combined with enzymes in order to create an efficient extraction system for valuable organic compounds . Many applications of ILs are embedded in agriculture where they are a useful bioactive chemical tool as, for example, adjuvants in pesticides and many more .…”