An efficient biocatalytic oxidative dehydroaromatization approach for the construction of quinolines enabled by monoamine oxidase with molecular oxygen

Abstract

An efficient biocatalytic approach for the oxidative dehydroaromatization of 1,2,3,4-tetrahydroquinolines by employing a monoamine oxidase PpMAO with molecular oxygen under mild conditions.

Selective electrochemical acceptorless dehydrogenation reactions of tetrahydroisoquinoline derivatives

“…Additives and generally harsh reaction conditions are often encountered in these processes. More importantly, 3,4-dihydroisoquinolines tend to undergo further dehydrogenation to form their stable aromatization products, 11 making it difficult to avoid their further oxidation, especially in the presence of external oxidants (Scheme 1b). Even though the above approaches have greatly enhanced the accessibility of 3,4-dihydroisoquinolines, new, safer, and environmentally friendly protocols, especially with high selectivity, are still highly desirable.…”

NBS-mediated bromination and dehydrogenation of tetrahydro-quinoline in one pot: scope and mechanistic study

“…Numerous examples include metal-complex catalysed acceptor less dehydrogenation, [19][20][21] along with aerobic oxidation catalyzed by Ru(phd) 3 , 22 Mn(Pc), 23 Co 3 O 4 -NGr/C, 24 and CuI/DEAD 25 etc. In addition, metal free catalytic systems, 26,27 photochemical methods, [28][29][30] and electrochemical methods 31 have also been reported. However, there are few reports on the simultaneous dehydrogenation and functionalization or halogenation of tetrahydroquinolines.…”