An Efficient Catalyst-Free Synthesis of Vinyl Sulfides in Aqueous-Phase

Abstract

An efficient catalyst-free synthesis of vinyl sulfides via the Michael addition of thiol compounds and tetrolic acid ester (or methyl propiolate) in water were carried out in good yields. The products were identified by IR, 1 H NMR and HRMS techniques. The structures of 5b, 6b and 8a were confirmed by X-ray diffraction analysis further. This protocol has the advantages of shorter reaction time, mild conditions, easy work-up and environmental friendliness.