The rapid utilization of electricity has forced the stability of the power system for continuous operation. Due to difference in demand and generation, the frequency reference point changes that needs to be restored to its locus point for the stable operation of the power system. Therefore, a novel efficient control design is propounded to counter the phenomena of load frequency control. The designing of cascaded fractional model predictive controller coupled with fractional-order PID controller (CFMPC-FOPID) is designed for an efficient response of the power system under load disruption and system parameter variations. The controller is optimized by sooty tern optimization algorithm to identify the optimal parameters of the controller. The controller is tested under power mixing of renewable energy sources (i.e., PV and wind) and under varying load scenarios in multiarea hybrid power system. The proposed controller has effectively handled the frequency disruption under distinct load change by stabilizing it in 1.34 sec, 0.60 sec, and 0.41 sec for area-1 with an average time of 0.78 sec, and for area-2, the stabilizing time is 1.40 sec, 0.89 sec, and 0.56 sec with an average time of 0.95 sec, whereas the average time for MPC/PI, DSA-FOPID, GWO: PI-PD, and SCA: FOPI-FOPID is 7.67 sec, 4.68 sec, 1.77 sec, and 4.72 sec, respectively, for area-1 and 6.47 sec, 5.13 sec, 3.45 sec, and 5.02 sec, respectively, for area-2. The outcome result justifies the superiority of the studied technique.