How to spot and summarize anomalies in dynamic networks such as road networks, communication networks and social networks? An anomalous event, such as a traffic accident, a denial of service attack or a chemical spill, can affect several near-by edges and make them behave abnormally, over several consecutive time-ticks. We focus on spotting and summarizing such significant anomalous regions, spanning space (i.e. nearby edges), as well as time.Our first contribution is the problem formulation, namely finding all such Significant Anomalous Regions (SAR). The next contribution is the design of novel algorithms: an expensive, exhaustive algorithm, as well as an efficient approximation, called NetSpot. Compared to the exhaustive algorithm, NetSpot is up to one order of magnitude faster in real data, while achieving less than 4% average relative error rate. In synthetic datasets, it is more than 30 times faster and solves large problem instances that are otherwise infeasible. The final contribution is the validation on real data: we demonstrate the utility of NetSpot for inferring accidents on road networks and detecting patterns of anomalous access to subnetworks of Wikipedia. We also study NetSpot's scalability in large social, transportation and synthetic evolving networks, spanning in total up to 50 million edges.