An efficient heterogeneous iron oxide nanoparticle catalyst for the synthesis of 9-substituted xanthene-1,8-dione

Trifluoroacetic acid-mediated synthesis of xanthene constructs and their extensive anti-tuberculosis evaluation

“…35 Besides, many more methods based on the reactions of 1,3-cyloalkadione with aromatic aldehydes have been also explored under various catalytic conditions. 36–39 To the best of our knowledge, this reaction has not been reported with trifluoroacetic acid (TFA) under ultrasonic conditions. We herein reported the formation of xanthene-analogue 14a by reacting 1,3-cyclohexadione with benzaldehyde in the presence of TFA in acetonitrile under ultrasonication conditions in almost quantitative yield without the need for column chromatography, Scheme 3.…”

“…35 Besides, many more methods based on the reactions of 1,3-cyloalkadione with aromatic aldehydes have been also explored under various catalytic conditions. [36][37][38][39] To the best of our knowledge, this reaction has not been reported with trifluoroacetic acid (TFA) under ultrasonic conditions. We Using this strategy, we have synthesized a diverse range of 25 compounds with varied cyclohexadione and benzaldehyde substitutions leading to xanthene-constructs having electron withdrawing/donating, halogen and phenolic substitutions, Table 1.…”

Efficient and reusable Pumice supported perchloric acid catalyst for concise and effective synthesis of 1,8-dioxo-octahydroxanthenes under solvent free condition

“…[7][8][9][10] Xanthendione are found as an important core in various natural products. Xanthene and their derivatives have shown crucial antimicrobial, 11 antimycobacterial, 12 antimalerial, 13 anticancer, 14 antihypertensive, 15 antiinflammatory, 16 antifungal, 17 antiplatelet, 18 antioxidant, 19 Many reports are available in the literature for the synthesis of 1,8-dioxo-octahydroxanthene by the condensation reaction of active methylene compounds with aldehydes in the presence of different catalytic materials such as Fe2O3 NPs, 20 TMSCl, 21 Perlite NPs@IL/ZrCl4, 22 β-cyclodextrin grafted with butyl sulfonic acid, 23 ZnS-Fe2O3-Ag Nanocomposite, 24 Barium Perchlorate, 25 TiO2/[(SO4) 2-], 26 thiourea dioxide, 27 FeNP@SBA-15, 28 ZnO NPs, 29 KF/Al2O3 or Silica Sulfate, 30 [HBIM][BF4]/US, 31 Amberlyst-15, 32 Cyanuric chloride, 33 Dowex-50W, 34 p-dodecyl benzene sulphonic acid, 35 SbCl3/SiO2, 36 silica sulphuric acid, 37 HClO4-SiO2, 38 and NaHSO4-SiO2, 39 triethylbenzyl ammonium chloride, 40 p-TSA, 41 etc. Although, in continuation of our investigation in view of the development of new eco-friendly routes for the synthesis of bioactive compounds using a novel less toxic catalyst, 2,3 we describe an effective and rapid method for the synthesis of 1,8-dioxo-octahydroxanthene using recyclable new pumice@HClO4 as a catalyst.…”

Fe3O4 Nanoparticles Catalyzed Tandem Synthesis of Fluorescent 3‐(4,5‐diaryl‐1H‐imidazol‐2‐yl) quinoline‐2‐amines: Solvatochromic, DFT and Biological Studies

“…[7,8] Advances in nanotechnology have led to a rise in the requirement for multifunctional materials, which are in high demand due to their recyclability and vast surface area. [9,10] Nanoparticles are intriguing for applications in industry and biomedicine and mainly in catalysis as magnetically separable catalysts. [11] Catalysts are widely used in many fields, particularly in organic synthesis.…”