This paper discusses a class of multilevel preconditioners based on approximate block factorization for conforming finite element methods employing quadratic trial and test functions. The main focus is on diffusion problems governed by a scalar elliptic partial differential equation with a strongly anisotropic coefficient tensor. The proposed method provides a high robustness with respect to non-grid-aligned anisotropy, which is achieved by the interaction of the following components: (i) an additive Schur complement approximation to construct the coarse-grid operator; (ii) a global block (Jacobi or Gauss-Seidel) smoother complementing the coarse-grid correction based on (i); and (iii) utilization of an augmented coarse grid, which enhances the efficiency of the interplay between (i) and (ii). The performed analysis indicates the high robustness of the resulting two-level method. Moreover, numerical tests with a nonlinear algebraic multilevel iteration method demonstrate that the presented two-level method can be applied successfully in the recursive construction of uniform multilevel preconditioners of optimal or nearly optimal order of computational complexity.In the general setting of an arbitrary elliptic operator, however, for quadratic FE discretizations the standard HB techniques do not result in splittings in which the angle between the coarse space and its hierarchical complement is uniformly bounded with respect to the mesh and/or the coefficient anisotropy, compare with [11]. The direct application of the two-level Schur complement-based preconditioner, as first suggested in [12], avoids the construction of an HB but still does not result in a robust multilevel algorithm as the numerical results in [13] demonstrate. The purpose of this work is to develop a class of robust multilevel methods for quadratic FE anisotropic elliptic problems. An essential building block of the preconditioners proposed in this paper is a technique referred to as additive Schur complement approximation (ASCA), which can be viewed as a generalization of the method introduced in [12], later also considered in [14][15][16], evolving the idea suggested in [17,18]. The ASCA algorithm is based on computing and assembling exact Schur complements of local (stiffness) matrices associated with a covering of the entire domain by overlapping subdomains.Although this technique was originally developed and described for elliptic problems with highly oscillatory coefficients discretized by linear and bilinear conforming FEs, it provides a basic tool for the solution of more general problems including non-symmetric and indefinite problems and using more general discretization techniques including non-conforming methods and higher order elements. In this article, ASCA is investigated for quadratic elements and strongly anisotropic elliptic problems with a main emphasis on non-grid-aligned anisotropy.Multilevel methods based on ASCA, similarly to element-based algebraic multigrid (AMG) [19,20] and smoothed aggregation multigrid, [21, 22] rely ...