An efficient one‐pot synthesis of 2‐aminopyrimidinomethylnaphtols under solvent‐free conditions

Abstract

A novel one-pot three-component condensation reaction of an aldehyde, 2-aminopyrimidine and 2-naphthol to afford the corresponding 2-aminopyrimidinomethylnaphtols in good yields. The remarkable features of this new procedure are high conversions, short reaction time, clean reaction profiles, and environmentally benign and simple work-up procedures. K E Y W O R D S2-aminopyrimidine, aryl aldehyde, solvent-free condition, β-Naphthol

Systematic studies on mechanochemical synthesis: Schiff bases from solid aromatic primary amines and aldehydes

“…The growing interest in mechanochemical processes has, in the past decade, provided exciting developments in the areas of supramolecular (cocrystals, capsules, catenanes, rotaxanes), pharmaceuticals (screening new solid drug forms, pharmaceutical cocrystals), materials (porous metal–organic frameworks, luminescent sensors), and organic (solvent‐free synthesis, solid‐state deracemization, organic cages) chemistry and catalysis (stereoselective organocatalysts, metal organic solvent‐free catalysis, catalytic solid‐state photoreactions) . These developments indicate that mechanochemistry will play a key role in future clean and sustainable technology, ranging from “green” synthesis to mineral manufacturing and nanoparticle synthesis.…”

A convenient route toward one‐pot multicomponent synthesis of spirochromenes and pyranopyrazoles accelerated via quinolinic acid

“…To address the above‐mentioned issues and in partial fulfillment of our ongoing projects in terms of developing an efficient protocol for the synthesis of heterocyclic molecules, herein, we have designated an efficient one‐pot, three‐component strategy for the synthesis of spirochromenes by condensation of enolizable C–H activated compounds 1 , malononitrile or ethyl cyanoacetate 2 , and various 1,2‐diketones 3 in aqueous ethanol at 70°C and also an efficient one‐pot, four‐component strategy for the effective synthesis of dihydropyrano[2,3‐c]pyrazoles and spiroindoline‐pyranopyrazoles from the condensation of hydrazine monohydrate 5 , ethyl acetoacetate 6 , malononitrile 2, and aldehydes 7 or isatins 3 under solvent‐free conditions in the presence of QUIN as an effective catalyst at 90°C (Scheme ).…”