An Efficient Route for Synthesis and Reactions of Seleno-[2, 3-c]coumarin

4‐Chlorothiazole‐5‐carbaldehydes as Potent Precursors for Synthesis of Some New Pendant N‐heterocyces Endowed with Anti‐Tumor Activity

“…Further, cyclocondensation of the chloroformyl 5 was achieved via treating with urea, thiourea, and guanidine hydrochloride to afford thiazolo [4,5-d]pyrimidine derivatives (12-14) (Scheme 2). The structures of isolated products (8)(9)(10)(11)(12)(13)(14) were confirmed based on their elemental analysis and spectral data. For instance, the IR spectrum of 13 stated characteristic absorption bands at 3326, 1615, and 1330 cm À1 because of NH str , C═N str , and C═S str groups, respectively.…”

“…As a part of our incessant efforts for the synthesis of various N-heterocycles [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], particularly annelated pyrazole, triazole, and thiazole analogues with biological importance, herein, we reported the synthesis of some novel pendant N-heterocyclic derivatives as biofunctional conjugates. The chloroformylthiazole-tagged and chlorothiazole-tagged intermediates 5 and 6 were prepared from 1 via three steps (Scheme 1).…”

“…As an extension of our research work [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15], we are aiming to merge chemical moieties of significant pharmacological activities for improving their therapeutic potentials, mainly, against profound diseases such as cancer which is a public health problem affecting millions of humans all over the world. In spite of enormous efforts, development new chemotherapeutic strategies for the improvement of potential anti-cancer drug, remains critically important [16].…”

Convenient Synthesis of Novel Nitrogen Bridgehead Heterocycles Utilizing 3‐Mercapto‐6H‐[1,2,4,5]oxatriazino[3,2‐a]isoindol‐6‐one as a New Synthon

“…Figure shows some of the reported biologically active isoindole, azine, and azole analogs. Thus, the aforesaid biological significance of these moieties compelled us to continue working on the synthesis and screening of new heterocyclic compounds containing N ‐heterocyclic systems resulting in more potent compounds.…”

Preparation of 2‐Arylethynylselanylacetonitriles from 4‐Aryl‐1,2,3‐selenadiazoles

“…For example, selanyl acetonitriles were utilized to prepare selenium-containing tetrazoles with antifungal activity, by cycloaddition of the nitrile group with sodium azide [2]. They have also been used to prepare selenium heterocycles with anti-inflammatory, analgesic, and antimicrobial activities [3,4]. Generally, selanyl acetonitriles have been prepared by substitution reactions using haloacetonitriles with selenolate ions, which were commonly accessed by the cleavage of diselenides [5,6].…”