An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4,5-dihydro-1,2,4-oxadiazoles

Kusurkar, Radhika S.; Chavan, Neelam L.; Naik, Nilesh H.; Nayak, Sandip K.

doi:10.3998/ark.5550190.0011.220

Cited by 2 publications

(1 citation statement)

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“…The reduction of amidoximes using triethylsilane (Et3SiH) as a reducing agent with the aid of palladium chloride in the presence of acetic acid gave amidines 7G (Scheme 23). 46 Scheme 23. Synthesis of amidines 7G using Et3SiH/PdCl2.…”

Section: Amidines From Carbodiimidesmentioning

confidence: 99%

Amidines: their synthesis, reactivity, and applications in heterocyclic synthesis

Aly¹,

Brï¿1⁄2se²,

Gomaa³

2018

Arkivoc

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The reactivity of amidines makes them valuable as building blocks for the synthesis of heterocyclic motifs of biological relevance, for functional materials, for organo-catalysts and as ligand in metal-complexes. As a large number of publications have recently reported on the reactivity of amidines, we compiled some features of these interesting molecules. Consequently, this article aims to review the preparation of functionalized amidines and to highlight their use as starting materials in the synthesis of various organic molecule classes, especially heterocyclic structures. In this review, we cover also related name reactions such as the Pinner reaction.

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Section: Amidines From Carbodiimidesmentioning

confidence: 99%

Amidines: their synthesis, reactivity, and applications in heterocyclic synthesis

Aly¹,

Brï¿1⁄2se²,

Gomaa³

2018

Arkivoc

View full text Add to dashboard Cite

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Synthesis of 2-(oxadiazolo, pyrimido, imidazolo, and benzimidazolo) substituted analogues of 1,4-benzodiazepin-5-carboxamides linked through a phenoxyl bridge

Kaur

Kishore

2014

J Chem Sci

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Exceedingly facile single-step expedient protocols based on the versatility and reactivity of corresponding intermediates amidine and imidate (8 and 9), derived from 5-carboxamido-1,4-benzodiazepin-5-(4'-methylpiperazinyl)-carboxamide have been developed to provide an easy installation of the oxadiazole, pyrimidine, imidazole and benzimidazole (9-14) based privileged templates at 2-position of 5-carboxamido-1,4-benzodiazepin-5-(4'-methylpiperazinyl)-carboxamide (4), through a phenoxyl spacer, by utilizing the synthetic strategy depicted in schemes 1 and 2.

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An efficient route towards the synthesis of monosubstituted N-aryl amidines from 4,5-dihydro-1,2,4-oxadiazoles

Cited by 2 publications

References 4 publications

Amidines: their synthesis, reactivity, and applications in heterocyclic synthesis

Amidines: their synthesis, reactivity, and applications in heterocyclic synthesis

Synthesis of 2-(oxadiazolo, pyrimido, imidazolo, and benzimidazolo) substituted analogues of 1,4-benzodiazepin-5-carboxamides linked through a phenoxyl bridge

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