“…Racemic approaches [ 10 , 11 ], chiral pool starting materials, asymmetric hydrogenation, classical/kinetic resolutions [ 12 , 13 ], regioselective aziridine ring openings with organocuprates [ 14 ], OsO 4 -catalyzed asymmetric dihydroxylations [ 15 ], and proline based functionalization of aldehydes [ 16 ] are the most reported synthetic strategies of ( R )-selegiline. In 2014, Pramanik and co-workers reported a deoxygenation of the pseudoephedrine approach to prepare ( R )-selegiline ( Figure 2 A) [ 17 ]. In the following year, Sudalai and co-workers employed Evans’ electrophilic azidation of chiral imide enolates as the key chiral-inducing step to synthesize ( R )-selegiline in high enantioselectivity (97%, R ) ( Figure 2 A) [ 18 ].…”