An efficient, simple and expedition synthesis of 1-amidoalkyl-2-naphthols as ‘drug like’ molecules for biological screening

Application of Surface Modified Magnetite as an Efficient Support for Heteropolyacids and Studying Its Catalytic Activity in Organic Synthesis

“…It was shown that the aromatic aldehydes with electron withdrawing groups reacted faster than their analogues with electron releasing groups. In contrast to the previously reported methods [10,11] , in which aliphatic aldehydes were not transformed into the corresponding 1-amidoalkyl-2-naphtols, they were converted into the desired product in good yields in the current methodology. Findings revealed that this protocol is effective for a wide range of aldehydes.…”

Facile One-Pot Synthesis of Amidoalkyl Naphthols and Benzopyrans Using Magnetic Nanoparticle-Supported Acidic Ionic Liquid as a Highly Efficient and Reusable Catalyst

“…These 1-amidoalkyl-2-naphthol and tetrahydrobenzo [b]pyran derivatives are of particular value because of their promising biological and pharmacological activities [7][8][9]. The preparation of amidoalkyl naphthols has been carried out by a three-component condensation of aldehydes, 2-naphthols and amides using different catalysts such as Ba 3 (PO 4 ) 2 [10], Nano Al 2 O 3 [11], supported heteropolyacid [12,13], magnetic sulfonic or phosphoric acid [14][15][16], β-CD-BSA [17], [C 6 [18], MWCNT@Co-complex [19], sulfonated polynapthalene [20] and grapheme oxide [21] in the last five years.Despite undeniable advantages of these methods, a great part of themsuffer from one or more shortcomings such as high reaction temperature, prolonged reaction time, low yield and difficult catalyst separation and recovery.…”

Facile One-Pot Synthesis of 1-Amidoalkyl-2-Naphthols by RuCl2(PPh3)3-Catalyzed Multi-Component Reactions

“…Although numerous methods for the synthesis of 1-amidoalkyl-2-naphthols have been reported, [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] there is still demand for simpler, less toxic, more effective, and milder catalysts. Our interest in developing a mild and efficient synthetic method that provides a variety of 1-amidoalkyl-2-naphthols has led us to looking into more convenient and safely usable catalysts.…”