An efficient synthesis and in vitro antibacterial evaluation of ruthenium–quinolinol complexes

Mahima, M.; Lakhani, Chirag; Chhabra, Mohit; Paira, Priyankar; Vidya, R

doi:10.1016/j.bmcl.2015.05.063

Cited by 11 publications

(12 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was previously reported that ruthenium-hydroxyquinolinato complexes exert fluorescence properties. [33] We have recorded fluorescence spectra in various solvents Figure S1) might be ascribed to the non-irradiative decay of excited states or the poor excitation efficiency of these organometallic ruthenium complexes, which are different from analogues of complex [Ru(bpy)3] 2+ . [44] Without SOG ability and photodynamic therapeutic activity, all these complexes were further investigated for their antitumor and antibacterial activity in normal condition without the photo-irradiation.…”

Section: Luminescence Properties Of Selected Ruthenium-hq Complexesmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines

Kljun

León

Peršič

et al. 2018

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

In this study we report the synthesis, characterization and a thorough biological evaluation of twelve organoruthenium-8-hydroxyquinolinato (Ru-hq) complexes. The chosen hqH ligands bear various halogen atoms in different positions which enables to study effect of the substituents on physico-chemical and biological properties. The determined crystal structures of novel complexes expectedly show the cymene ring, a bidentately coordinated deprotonated hq and a halide ligand (chlorido or iodido) coordinated to the ruthenium central ion. In previous studies the anticancer potential of organoruthenium complex with 8-hydroxyquinoline ligand clioquinol was well established and we have decided to perform an extended biological evaluation (antibacterial and antitumor activity) of the whole series of halo-substituted analogs. Beside the cytotoxic potential of studied compounds also the effect of two selected complexes (9 and 10) on apoptosis induction in MG-63 and A549 cells was also studied via externalization of phosphatidylserine at the outer plasma membrane leaflet. Both selected complexes that gave best preliminary cytotoxicity results contain bromo substituted hq ligands. Apoptosis induction results are in agreement with the cell viability assays suggesting the higher and more selective anticancer activity of complex 10 in comparison to complex 9 on MG-63 cells.

show abstract

Section: Luminescence Properties Of Selected Ruthenium-hq Complexesmentioning

confidence: 99%

“…Another study of Malipeddi et al [33] was recently published involving organoruthenium complexes and their antibacterial properties. However, this study in absence of structural data proposes incorrect structures of the synthesized complexes (1, 2, 5) in which the hqH ligand is presumed to be coordinated in a neutral form.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines

Kljun

León

Peršič

et al. 2018

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

show abstract

“…The SMs 3a–3d were dissolved in DMSO at a concentration of 1000 or 2000 µg/ml. Ciprofloxacin (50 µg/ml) were used as standard drug and DMSO as a control for the comparison of antibacterial activity and antifungal activity [28, 32]. The zone of inhibition was compared with a standard drug after 24 h of incubation at 37 °C for antibacterial activity.…”

Section: Resultsmentioning

confidence: 99%

“…Even though the antifungal activity was drastically increased for the 2000 µg/ml concentration against C. albicans, but the activity was ten times lower than the standard ciprofloxacin. The SMs 3a–3d showed no antibacterial efficacy against K. pneumoniae and S. aureus strains due to the different cell wall structure [22, 28, 32]. Mainly, SM 3a and 3c showed better antibacterial and antifungal activities than the 3b and 3d due to comparatively smaller structure.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and studies of bay‐substituted perylene diimide‐based D–A–D‐type SM acceptors for OSC and antimicrobial applications

Ganesamoorthy

Vidya

Sakthivel

2017

IET nanobiotechnol.

View full text Add to dashboard Cite

In this study, the synthesis of a series of bay-substituted donor-acceptor-donor (D-AD) type perylene diimide derivatives (3a-3d) has been reported as an acceptor for the small-molecule-based organic solar cells (SM-OSCs) by the Suzuki coupling method. It has been evaluated for the antimicrobial activity against some of the bacteria and fungi. The synthesised SMs were confirmed by Fourier transform-infrared spectroscopy, nuclear magnetic resonance (NMR), and high resolution mass spectroscopy (HR-MS). The SMs showed absorption up to 750 nm, which eventually reduced the optical band gap E g opt to < 2 eV. SMs showed thermal stability up to 400 °C. In the SM-OSC, the SMs showed a power conversion efficiency of < 1% with the P3HT donor in bulk hetero-junction device structure. Additionally, the new SMs showed antimicrobial activity against Gram-negative bacteria such as Escherichia coli Gram-positive bacteria such as Bacillus subtilis and antifungal activity against the Candida albicans, and Aspergillus niger. Cytotoxicity studies were carried out against the breast cancer cell lines MCF-7 using MTT assay method. The results revealed that the SMs was able to inhibit the cancer cells. LD 50 s calculated for the SMs 3a-3d were between 200 and 400 µg/ml.

show abstract

“…Bioactive compounds are observed to exhibit improved biological activity upon coordination with transitional metal ions [79,80]. Paira and team [81] have synthesized few Ru(II)-arene complexes of benzimidazole, benzoxazole, and benzothiazole ( Fig.…”

Section: Benzoxazole-metal Complexesmentioning

confidence: 99%

Anticancer activity of benzoxazole derivative (2015 onwards): a review

Ghoshal

Patel

2020

Futur J Pharm Sci

View full text Add to dashboard Cite

Background According to the report published recently by the World Health Organization, the number of cancer cases in the world will increase to 22 million by 2030. So the anticancer drug research and development is taking place in the direction where the new entities are developed which are low in toxicity and are with improved activity. Benzoxazole and its derivative represent a very important class of heterocyclic compounds, which have a diverse therapeutic area. Recently, many active compounds synthesized are very effective; natural products isolated with benzoxazole moiety have also shown to be potent towards cancer. Main text In the last few years, many research groups have designed and developed many novel compounds with benzoxazole as their backbone and checked their anticancer activity. In the review article, the recent developments (mostly after 2015) made in the direction of design and synthesis of new scaffolds with very potent anticancer activity are briefly described. The effect of various heterocycles attached to the benzoxazole and their effect on the anticancer activity are thoroughly studied and recorded in the review. Conclusion These compiled data in the article will surely update the scientific community with the recent development in this area and will provide direction for further research in this area.

show abstract

An efficient synthesis and in vitro antibacterial evaluation of ruthenium–quinolinol complexes

Cited by 11 publications

References 45 publications

Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines

Synthesis and biological characterization of organoruthenium complexes with 8-hydroxyquinolines

Synthesis and studies of bay‐substituted perylene diimide‐based D–A–D‐type SM acceptors for OSC and antimicrobial applications

Anticancer activity of benzoxazole derivative (2015 onwards): a review

Contact Info

Product

Resources

About