An efficient synthesis of 3-alkyl-1,5,3-dioxazepanes and their use as electrophiles in double-Mannich reactions

Sparrow, Kevin; Barker, David; Brimble, Margaret A.

doi:10.1016/j.tet.2011.11.090

Cited by 21 publications

(2 citation statements)

References 23 publications

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“…The full list of compounds screened can be found in Supplementary Table S1 . The compounds in this set were produced during extensive synthetic work towards a range of diverse bioactive natural products and related scaffolds [ 31 , 32 , 39 , 40 , 47 , 60 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ]. Additional information on individual compounds is available upon request.…”

Section: Methodsmentioning

confidence: 99%

Screening a Natural Product-Inspired Library for Anti-Phytophthora Activities

et al. 2021

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Phytophthora is a genus of microorganisms that cause devastating dieback and root-rot diseases in thousands of plant hosts worldwide. The economic impact of Phytophthora diseases on crops and native ecosystems is estimated to be billions of dollars per annum. These invasive pathogens are extremely difficult to control using existing chemical means, and the effectiveness of the few treatments available is being jeopardized by increasing rates of resistance. There is an urgent need to identify new chemical treatments that are effective against Phytophthora diseases. Natural products have long been regarded as “Nature’s medicine chest”, providing invaluable leads for developing front-line drugs and agrochemical agents. Here, we have screened a natural product-inspired library of 328 chemicals against two key Phytophthora species: Phytophthora cinnamomi and Phytophthora agathidicida. The library was initially screened for inhibition of zoospore germination. From these screens, we identified twenty-one hits that inhibited germination of one or both species. These hits were further tested in mycelial growth inhibition studies to determine their half-maximal inhibitory concentrations (IC50s). Four compounds had IC50 values of approximately 10 µM or less, and our best hit had IC50s of approximately 3 µM against both Phytophthora species tested. Overall, these hits may serve as promising leads for the development of new anti-Phytophthora agrochemicals

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Section: Methodsmentioning

confidence: 99%

Screening a Natural Product-Inspired Library for Anti-Phytophthora Activities

et al. 2021

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“…To nd the best activator for the desired transformation, a variety of Lewis acids were screened, and methyltrichlorosilane appeared as the best candidate (Scheme 106). 205 3.4.3. Cycloaddition reaction.…”

Section: O-cyclizationmentioning

confidence: 99%