Abstract:A new AgOTf‐catalyzed domino reaction of 2‐alkynylbenzaldehyde and 4‐amino‐1‐methyl‐3‐propyl‐1H‐pyrazole‐5‐carboxamide has been reported via a sequential condensation, cyclization, and acetylenic hydroamination process. The developed protocol provides an efficient and modular access to a range of new fused tetracyclic heterocycle 6‐aryl‐9‐methyl‐11‐propyl pyrazolo[4′,3′:4,5]pyrimido[2,1‐a]isoquinolin‐8(9H)‐ones with two new rings in good yields.
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