An Efficient Synthesis of 8-Hydroxy-6,7-dimethoxy-3-methylisocoumarin (6-O-methylreticulol)

Methyl 3,4,5-trimethoxybenzoate

“…For related literature, see: Hellyer et al (1966); Cooke & Rainbow (1974); Suzuki et al (2004); Aboul-Enein & Eid (1979); Tanaka et al (2001); Saeed & Ehsan (2005a, 2005b; Saeed (2007). For bond-length data, see: Allen et al (1987).…”

3-(2-Bromophenyl)isocoumarin

“…Isocoumarins are useful intermediates (Hauser & Baghdanor, 1988;Mali & Babu, 1998) in the synthesis of a variety of natural products. We have reported the syntheses of a number of naturally occurring and synthetic isocoumarins (Saeed, 2003a(Saeed, ,b, 2004aSaeed & Ehsan, 2005). 3-Halophenylisocoumarins are not known in nature and are expected to display a number of bioactivities.…”

Ultrasound Assisted Synthesis of 3, 4-Disubstituted Isocoumarins and their Biological Evaluation

“…Isocoumarins are a class of privileged heterocyclic scaffolds which features as core structures in many naturally occurring compounds [1][2][3] . Over a period of time, Isocoumarins have become one of the most important classes of organic compounds due to their widespread biological activities [4][5][6] and usefulness to build several pharmaceutical and natural products [7][8] . Among the variety of substituted isocoumarins, the 3,4-disubstituted variants are significant because of their biological activities [9][10] .…”