An efficient synthesis of carbon‐14 labelled vigabatrin

Abstract

Vigabatrin-[6-14C] ((R,S)-4-amino-5-hexenoic-[6-14C] acid)was synthesized by employing Wittig condensation of 1-(1butenyl)-2-oxo-5-pyrolidinecarboxaldehyde with methyl-[ 14C]-triphenylphosphonium iodide as the key step. The synthetic sequence involved 3 steps and produced the title compound in 70% overall yield with a radiochemical purity of 100%.

Synthesis and properties of novel polyimide fibers containing phosphorus groups in the main chain

“…Synthesis of methyl triphenylphosphonium iodide (MTI) 1 (ref. [31][32][33]. CH 3 I (7.5 mol, 1064 g) was slowly added into a chilled solution of 7.5 mol Ph 3 P (1967.18 g) in 6 L of toluene, which was reacted in a 10 L round bottom ask in the ice bath.…”

Novel synthesis of [1‐11C]γ‐vinyl‐γ‐aminobutyric acid ([1–11C]GVG) for pharmacokinetic studies of addiction treatment

“…[11][12][13][14][15] For example, a procedure to prepare the key 2-oxopyrrolidine-5-carboxaldehyde precursor that would in principle allow the incorporation of C-11 by employing the Wittig condensation with [ 11 C]methyltriphenylphosphonium iodide (Scheme 1) was not straightforward. [14][15][16] We experienced this in our initial trials, and other researchers (authors in References 14,15 ) made similar observations.…”