An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and Pd‐Catalyzed Intramolecular Lactonization.

Abstract

An Efficient Synthesis of Coumestrol and Coumestans by Iodocyclization and Pd-Catalyzed Intramolecular Lactonization. -The method allows the preparation of a wide variety of related compounds which are of biological interest. -(YAO, T.; YUE, D.; LAROCK*, R. C.; J. Org. Chem. 70 (2005) 24, 9985-9989; Dep. Chem., Iowa State Univ., Ames, IA 50011, USA; Eng.) -Jannicke 14-223

Regioselective 5-exo-Trig Heterocyclization of 2-Allyl-1-naphthols under the Influence of N-Iodosuccinimide or Molecular Iodine in Aqueous Micelle

“…In recent years, there has been a flurry of reports for the synthesis of a large number of biologically active heterocycles [31][32][33][34][35] via molecular-iodine-mediated iodocyclization reactions as iodine is inexpensive, easily available, and nontoxic in nature, and additionally iodonium-annulated heteroannulations are extremely effective because they offer an alternative pathway and as a result of which the synthesis of complex molecules, which are not always accessible by the use of common organometallic reagents, becomes easier.…”