An Efficient Synthesis of Heterogeneous and Hard Bound Ti^IV‐MCM‐41 Catalyzed Mannich Bases and π‐Conjugated Imines

Abstract

A heterogeneous and hard bound TiIV anchored MCM‐41 material has been successfully evaluated for catalytic applications in the one pot synthesis of highly functionalized β‐amino ketones and quinoline appended π‐conjugated imines via Mannich reaction and condensation reaction, respectively. The synthetic transformation was successfully catalyzed via the dual Bronsted and Lewis acetic nature of the Ti‐MCM‐41 material that provided excellent yields of the desired products. The heterogeneous catalyst shows good catalytic performance, facile separation from the reaction mixture and can be reused in more than five catalytic cycles without any significant loss in the yield.

Active Hydrogen Free, Z-isomer selective, isatin derived “Turn on” fluorescent dual anions sensor

“…Ti-MCM-41 catalyst was synthesized based on our previous report [101]. Ti-MCM-41 catalyst was used as catalyst for the synthesis of imine [99]. The synthesis of N-propargyl isatin is given in the Scheme 1.…”

“…for this reason, the letter is indented to investigate the liquid-state sigma-hole interaction of isatin derivatives. We have recently disclosed Ti-MCM-41 catalyzed quinoline appended conjugated oxindole derivatives via condensation approach [99], re ecting our interest in the realm of isatin based synthetic transformation. The ability of the synthetic conjugated imine 1-(prop-2-yn-1-yl)-3-(quinolin-3ylimino)indolin-2-one (PQI) to recognize different anions has been evaluated.…”