An Efficient Synthesis of Novel Aminothiazolylacetamido-Substituted 3,5-Bis(arylidene)-4-piperidone Derivatives and Their Cytotoxicity Studies

Suresh, Thangaiyan; Nachiappan, Dhatchana Moorthy; Karthikeyan, G.; Vijayakumar, Vijayaparthasarathi; P Jasinski, Jerry; Sarveswari, Sundaramoorthy

doi:10.1021/acsomega.4c00039

ACS Omega

2024

DOI: 10.1021/acsomega.4c00039

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An Efficient Synthesis of Novel Aminothiazolylacetamido-Substituted 3,5-Bis(arylidene)-4-piperidone Derivatives and Their Cytotoxicity Studies

Thangaiyan Suresh,

Dhatchana Moorthy Nachiappan,

G. Karthikeyan

et al.

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Cited by 4 publications

References 37 publications

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Cobalt‐Catalyzed Synthesis of Functionalized Nordazepams and Benzimidazoquinazolines and Their Photophysical Properties

Suresh,

Keerthana,

Khan

2024

Asian J Org Chem

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An efficient and environmentally friendly one‐pot sequential synthesis of functionalized nordazepam and a benzimidazoquinazoline analogue is reported, utilizing cobalt as the metal catalyst. The reaction proceeds via either the α‐alkenylation or dehydrogenative sp3 C‐H functionalization pathway. This transformation includes mild reaction conditions, operational simplicity, and good functional group tolerance. Additionally, this method is suitable for the gram‐scale synthesis of functionalized nordazepam and benzimidazoquinazoline compounds. Furthermore, the synthetic utility, photophysical properties and real‐life application of the synthesized derivatives were explored.

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Cobalt‐Catalyzed Synthesis of Functionalized Nordazepams and Benzimidazoquinazolines and Their Photophysical Properties

Suresh,

Keerthana,

Khan

2024

Asian J Org Chem

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Ligand‐Free Zn Catalyzed Synthesis of Functionalized Indoloacridines

Sambavi,

Nawaz Khan

2024

Asian J Org Chem

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An efficient, ligand‐free, and Zn‐catalyzed dehydrogenation of acridinol/ cyclization of imine product/ dehydrogenative C(sp3)‐H functionalization utilizing ChCl‐based deep eutectic solvent system for the assembly of functionalized indoloacridines 9 is reported. The protocol features mild reaction conditions, VOCs free process, broad substrate scope, and applicable gram‐scale synthesis. Furthermore, absorption and solvatochromism properties were explored for the synthesized compounds.

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Design, synthesis, structural, in silico, and in vitro exploration of structurally modified hydrazones of piperidin-4-one with acetyl & ester moieties

Karthiga,

Divyabharathi,

Reshwen Shalo

et al. 2025

Journal of Molecular Structure

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An Efficient Synthesis of Novel Aminothiazolylacetamido-Substituted 3,5-Bis(arylidene)-4-piperidone Derivatives and Their Cytotoxicity Studies

Cited by 4 publications

References 37 publications

Cobalt‐Catalyzed Synthesis of Functionalized Nordazepams and Benzimidazoquinazolines and Their Photophysical Properties

Cobalt‐Catalyzed Synthesis of Functionalized Nordazepams and Benzimidazoquinazolines and Their Photophysical Properties

Ligand‐Free Zn Catalyzed Synthesis of Functionalized Indoloacridines

Design, synthesis, structural, in silico, and in vitro exploration of structurally modified hydrazones of piperidin-4-one with acetyl & ester moieties

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