An efficient synthesis of novel 1,3-oxazolo[4,5- d ]pyridazinones

An Efficient Synthesis and Reactions of Novel Indol-ylpyridazinone Derivatives with Expected Biological Activity

“…Reaction of chloropyridazine 4b with hydrazine hydrate in boiling benzene [34] gave the hydrazinopyridazine derivative 9, whose structure was inferred from its infrared spectrum. The structure of 9 was further confirmed by its reaction with acetyl acetone in boiling methanol that gave 3-anthracen-9-yl-6-(3,5-dimethylpyrazol-1-yl) pyridazine (10) [5,6,14,32]. As a point of interest, it was observed that reaction of 4b with methylamine at 140 °C afforded 11.…”

“…The structure of 4b was proven by the similarity of its melting point to that of an authentic sample which was independently prepared by the reaction of 4-anthracen-9-yl-4-oxo-but-2-enoic acid (1) with hydrazine hydrate in dry benzene and treatment of the resulting pyridazinone 8 with POCl 3 for 30 min to give 4b (Scheme 3) [1,5,7,30,31]. Reaction of chloropyridazine 4b with hydrazine hydrate in boiling benzene [34] gave the hydrazinopyridazine derivative 9, whose structure was inferred from its infrared spectrum.…”

“…In recent years a substantial number of 6-aryl-3-(2H)-pyridazinones have been reported to possess antimicrobial [1,2], potent analgesic [3], anti-inflammatory [3][4][5][6][7], antifeedant [8], herbicidal [9], antihypertensive [10][11][12] and antiplatelet activities [13][14][15], anticancer effects [16] and other anticipated biological [17] and pharmacological properties [18,19]. In particular, a large number of indolylpyridazinone derivatives are well known as antimicrobial agents [1,20], intermediates for drugs and agrochemicals [21,22], antiphlogistics [23], antipyretics [24], inflammation inhibitors [25], blood platelet aggregation inhibitors, cardiovascular and antihypertensive agents [26].…”

Synthesis and Antimicrobial Activities of Some New Thieno and Furopyrimidine Derivatives

“…Further more, many condensed heterocyclic systems, especially when linked to a pyrimidine ring as thienopyrimidine play an important role as potent analgesic [1], anti-inflammatory [1][2][3][4][5], antipyretic [6][7][8], antimicrobial [9][10], anticonvulsant [11], fungicidal [12], antiplatelet activities [13][14][15], and other central nervous system (CNS) affecting activities [16]. In addition, pyrimidine nucleus can be found in a broad variety of antibacterial, anticancer and anti-tumor agents as well as in agrochemicals and veterinary products [17][18].…”

Convenient synthesis of some methyl-N-[2-(3-oxo-6-p-tolyl-2,3,4,5-tetrahydropyridazin-2-yl)-acetylamino]amino acid esters

“…Recently, a number of 6-aryl-4,5-dihydropyridazin-3(2H)-ones have been reported to possess antimicrobial, 1,2 potent analgesic, 3 anti-inflammatory, [3][4][5][6][7] antifeedant, 8 herbicidal, 9 antihypertensive, [10][11][12] antiplatelet activities, [13][14][15] anticancer effects 16 and other anticipated biological 17 and pharmacological properties. 8,19 Imazodan I is reported to show ionotropic properties comparable to milrinone and amrinone II.…”