An efficient synthesis of pyrrolo[2,1-c][1,4]benzodiazepine antibiotics via reductive cyclization

Facile Preparation of Hydrazones by the Treatment of Azides with Hydrazines Catalyzed by FeCl3·6H2O

“…To that end we began an investigation in which a series of simple azides were treated with N , N -dimethylhydrazine/ferric chloride. Coincident with the outset of our research, a report by Kamal and co-workers appeared in which a series of azides, when treated with virtually the same reagent/catalyst system, produced the corresponding amines in reasonable yields . While initially disappointed, we soon realized that our initial results were in stark contrast to those of Kamal .…”

Design and Synthesis of Novel Pyrrolo[2,1-c][1,4]benzodiazepine−Lexitropsin Conjugates

“…Since the synthesis of the PBD ring system itself is problematic, due to the labile N10−C11 imine moiety (carbinolamine or methyl ether equivalent), much of the literature to date has focused on the development of new synthetic strategies. , In contrast, very little has been reported about modifications on the PBD ring system or conjugation with carriers . Recently, a C8-linked PBD dimer was prepared 7 which forms a symmetric interstrand cross-link with duplex DNA involving a four-base pair bonding site but spanning six DNA base pairs overall .…”