An Efficient Synthetic Method for the Synthesis of Novel Pyrimido[1,2-a]pyrimidine-3-carboxylates: Comparison of Microwave and Conventional Heating

Bayramoğlu, Duygu; Güllü, Mustafa

doi:10.1080/10406638.2021.1915806

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…They attributed the effectiveness of EG to the intramolecular Hbond formed between EG and acetoacetate. Bayramoğlu et al [13] utilized microwave irradiation (MW) to synthesize the fused pyrimidinone compound 5 from pyrimidin-2-amine (1 b, 1.0 equiv.) and diethyl ethoxymethylenemalonate (EMME, 4, 1.1 equiv.)…”

Section: Reaction With 13-dicarbonyl Compoundsmentioning

confidence: 99%

Synthesis of Fused Imidazoles and Pyrimidinones from 2‐Aminoazines

Wang,

Jiang,

Liu

et al. 2024

Asian J Org Chem

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Fused imidazole and pyrimidine heterocycles represent two important classes of organic compounds. Numerous synthetic methods have been developed for the synthesis of these compounds due to their diverse biological activities and potential pharmaceutical applications. This review provides a comprehensive assessment of the cutting‐edge methods used in the synthesis of fused heterocycles from pyridin‐2‐amines and their aza derivatives involving reaction with 1,3‐dicarbonyl compounds or α‐halo carbonyl compounds. In addition, the Groebke‐Blackburn‐Bienaymé (GBB) reaction, metal‐mediated reactions and other related reaction systems have been considered. We summarize the pertinent literature on related synthetic methods in the period 2020 to 2023. The analysis provided can inform future developments directed at new cost‐effective approaches to the synthesis of fused imidazole and fused pyrimidine analogues.

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Section: Reaction With 13-dicarbonyl Compoundsmentioning

confidence: 99%

Synthesis of Fused Imidazoles and Pyrimidinones from 2‐Aminoazines

Wang,

Jiang,

Liu

et al. 2024

Asian J Org Chem

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“…Our previous study provided a new approach for the synthesis of novel pyrimido[1,2a]pyrimidines in high yields by reactions of 2-aminopyrimidines with diethyl ethoxymethylenemalonate (EMME) using microwave irradiation and conventional heating and published elsewhere [15]. For this purpose, in present research, it was firstly aimed to synthesize novel pyrimido[1,2-a]pyrimidines and investigate their antibacterial activity by broth microdilution method in agreement with European Committee on Antimicrobial Susceptibility Testing (EUCAST) standards [16] and antioxidant activity with the use of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay [17,18], which are hitherto unknown in the literature.…”

Section: Figure 2 Design Strategy Of Pyrimido[12-a]pyrimidinesmentioning

confidence: 99%

“…A series of novel pyrimido[1,2-a]pyrimidine derivatives containing electron-withdrawing and electron-donating substituents on the ring have been successfully synthesized. All spectral analyzes and characterizations were performed and published in a previous study [15].…”

Section: Synthesismentioning

confidence: 99%

“…The basic synthetic process consists of two steps; syntheses of 4substituted 2-aminopyrimidines and then cyclization of these 2-aminopyrimidines with EMME in onestep under optimal conditions. Consequently, pyrimido[1,2-a]pyrimidines derivatives bearing one substituent (CH3, pyrrolidinyl, piperidinyl and/or morpholinyl) at the 8-position have been synthesized with good yields Figure 3 [15].…”

Section: Synthesis Of Pyrimido[12-a]pyrimidinesmentioning

confidence: 99%

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A STUDY ON ANTIOXIDANT and ANTIBACTERIAL ACTIVITY COMPARISON of NEW PYRIMIDO[1,2-a]PYRIMIDINE COMPOUNDS

Bayramoğlu

ÖZ>²,

Kiymaci

2022

Ankara Ecz. Fak. Derg.

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Objective: Antioxidant capacity and antibacterial activity of a series of new pyrimido[1,2-a]pyrimidines were investigated Material and Method: All these novel compounds were screened for their in vitro antioxidant effectiveness using DPPH radical scavenging test and the antibacterial activity was determined using the both microdilution method according to The European Committee on Antimicrobial Susceptibility Testing standards as a minimal inhibition concentration against some Gram positive and negative ATCC strains. Result and Discussion: As a result, some of the selected compounds showed weak to moderate antioxidant activity. MIC values of all compounds were found > 100 µg/ml against Staphylococcus aureus ATCC 29213, methicillin resistant Staphylococcus aureus ATCC 43300, Enterococcus faecalis 29212, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, Pseudomonas aeruginosa ATCC 27853.

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