An eight-year experience with porcine bioprosthetic cardiac valves

Hartz, Renée S.; Fisher, Elysa B.; Finkelmeier, Betsy A.; DeBoer, Arthur; Sanders, John H.; Moran, John M.; Michaelis, Lawrence L.

doi:10.1016/s0022-5223(19)35970-7

Cited by 49 publications

(12 citation statements)

References 23 publications

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“…Despite these concerns, xenografts have already been implanted into the central nervous system of patients with Parkinson's disease 76 -82 and avascular xenografts of porcine tissue have been used for cardiac valve transplantation. [83][84][85][86] The role of xenografts in the management of RPEmediated disease or dysfunction remains to be determined.…”

Section: Barriers To Successful Rpe Transplantationmentioning

confidence: 99%

Triple Immune Suppression Increases Short-Term Survival of Porcine Fetal Retinal Pigment Epithelium Xenografts

Priore

Ishida

Johnson³

et al. 2003

Invest. Ophthalmol. Vis. Sci.

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Section: Barriers To Successful Rpe Transplantationmentioning

confidence: 99%

Triple Immune Suppression Increases Short-Term Survival of Porcine Fetal Retinal Pigment Epithelium Xenografts

Priore

Ishida

Johnson³

et al. 2003

Invest. Ophthalmol. Vis. Sci.

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“…10 Double valve replacement has become routine for patients with double valve disease in many centers. 2,3 Technically the operation is quite feasible, and the long term results were satisfactory. However, it is our opinion that all conservative efforts on the aortic valve are well justified in order to avoid introducing the specific problems derived from a single prosthesis.…”

Section: Discussionmentioning

confidence: 93%

“…1 Around 9.3 to 13.7% of patients with valvular heart disease have involvement of both the aortic and mitral valves. 2,3 Although many groups perform simultaneous aortic and mitral valve replacement for such patients, 1 some data suggest a survival advantage for aortic valve replacement combined with mitral valve repair. 4 In our institution, we have tried to preserve the patient's valves by using the aortic and mitral valve repair technique as long as possible, 5 –7 especially in cases of degenerative disease.…”

Section: Introductionmentioning

confidence: 99%

Combined Aortic and Mitral Valve Repair

Kazui

Kin

Izumoto

et al. 2003

Asian Cardiovasc Thorac Ann

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Six patients, median age 63.3 years (range, 54 to 68 years), underwent concomitant mitral and aortic valve repair from January 2000 to August 2001. Surgical reports and general clinical data were reviewed retrospectively. All patients had degenerative valvular disease, although one patient also had annuloaortic ectasia. There were no surgical complications. The 30 day survival rate was 100%, and the New York Heart Association classification score improved from 2.2 (range, 1 to 2) preoperative, to 1.0 (all patients) postoperatively (p = 0.03) As measured by intraoperative transesophageal echocardiography, the left ventricular end-diastolic diameter decreased from 6.0 cm (range, 5.4 to 6.3 cm) to 4.7 cm (range, 4.0 to 5.2 cm) and the left ventricular end-systolic diameter decreased from 3.7 cm (range, 3.4 to 4.1cm) to 3.1 cm (range, 2.9 to 3.7 cm). No patient developed endocarditis, thromboembolism or hemorrhage. There was no valve related morbidity during a 1 year follow up. Double valve repair is an acceptable alternative to valve replacement in selected patients with some types of valvular disease. Longer term follow up with greater numbers of patients is needed.

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“…2 10% of patients with valvular heart disease present with involvement of both mitral and aortic valve. [3][4][5][6] Though the benefits of isolated…”

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confidence: 99%

Short Term Outcome of Double Valve Replacement vs. Aortic Valve Replacement with Mitral Valve Repair in Bangladesh: A Comparison

Rokonujjaman¹,

Ahmad²,

Islam³

et al. 2021

Cardiovasc. j.

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Background: Although all mitral valves are not repairable, most non rheumatic valves and a substantial proportion of rheumatic valves are amenable to repair. Repair preserves the normal valvular tissue, so the left ventricular function is well maintained post-operatively. Combined aortic and mitral valve surgery is associated with increased mortality and morbidity. Several studies have shown the superiority of DVR (Double valve replacement) in this entity to prevent reoperation. Some other data suggested superiority of aortic valve replacement combined with mitral valve repair in double valve disease. No study had been done over Bangladeshi population. Our aim was to compare the short-term outcome of mitral valve repair and aortic valve replacement with double valve replacement. Methods: It was a prospective non-randomized observational study took place in the Department of Cardiac Surgery of National Institute of Cardiovascular Disease. In this study post-operative result of double valve replacement was compared with aortic valve replacement and mitral valve repair. Total 60 patients under went aortic valve replacement with either mitral valve replacement (n=30) marked as group A or (n=30) repair marked as Group B. Results: Aortic cross clamp time and cardiopulmonary bypass time was higher in group B than group A but it was well tolerated without any short-term measurable consequences. Required inotrope support was 49.8±2.3 hours in group B and 87.2±3.5 hours in group A (p<0.05). Duration of ICU stay were 91.1±3.2 hours in group A and 60.3±2.9 hours in group B (p<0.05). Development of postoperative low output syndrome was significantly higher (23.33%) in group A versus 3.33% in group B. Patients of group A suffered more from CHF in the follow up period than the group B. But the result was statistically insignificant. There was an early post-operative fall of ejection fraction in both groups but it was recovered after 3 months. Post-operative thromboembolism was 13.79% in group A and 3.33% in group B. There was no early death in repair group though total three (10%) cases died after DVR. There was no valve failure, re-stenosis or regurgitation in any group in this limited follow up period. Higher dose of warfarin was required in group A to maintain INR. Consequently, post-operative major bleeding occurred in 24.14% patients of group A. On the contrary, no patient of repair group suffered from this catastrophe. Conclusion: This study reveals that the result of mitral valve repair with aortic valve replacement is equally comparable or in some cases superior to that of double valve replacement. Therefore, in feasible cases, mitral valve repair should be attempted who need concomitant aortic valve replacement. Cardiovasc. j. 2021; 13(2): 164-171

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An eight-year experience with porcine bioprosthetic cardiac valves

Cited by 49 publications

References 23 publications

Triple Immune Suppression Increases Short-Term Survival of Porcine Fetal Retinal Pigment Epithelium Xenografts

Triple Immune Suppression Increases Short-Term Survival of Porcine Fetal Retinal Pigment Epithelium Xenografts

Combined Aortic and Mitral Valve Repair

Short Term Outcome of Double Valve Replacement vs. Aortic Valve Replacement with Mitral Valve Repair in Bangladesh: A Comparison

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