An Elderly Patient with Gastric Carcinoma Developing Multiple Metastasis in Skeletal Muscle.

Oba, Koji; Ito, Tami; Nakatani, Chizuko; Okamura, Kojiro; Yamaguchi, Hiroshi; Ajiro, Yumiko; Suzuki, Tatsuya; Nakano, Hiroshi; Metori, Shouhei; Sano, Kazufumi; Hyakusoku, Hiko; Yamada, Nobutaka

doi:10.1272/jnms.68.271

Cited by 17 publications

(11 citation statements)

References 8 publications

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“…1 Remote dissemination of a malignancy to muscle occurs in Ͻ5% of all cases of systemic metastasis, although direct muscle invasion from adjacent organs is not an uncommon occurrence. 2 In relatively few cases of muscle metastasis (MM), adenocarcinoma from either the lung or the gastrointestinal tract is the most frequent source, with squamous cell and renal carcinoma occurring less often. 3 In each, there is a statistically greater chance of metastasis to the paraspinal muscle (Fig.…”

mentioning

confidence: 99%

Paucity of Muscle Metastasis in Otherwise Widely Disseminated Cancer

LaBan¹,

Nagarajan²,

Riutta³

2010

American Journal of Physical Medicine &Amp; Rehabilitation

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Despite widespread dissemination of cancer to multiple organs, muscle metastasis remains a rare occurrence. Limiting factors in this regard include, among others, repetitive muscle contraction, increased lactic acid, and decreased pH as well as protease metabolism. With the approval of hospital's research committee, a 10-yr review of histopathologic and imaging studies of patients diagnosed as having muscle metastasis was attempted. A review of the literature dealing with this phenomenon was also initiated. The review of the literature with reference to muscle metastasis highlighted its rare occurrence, which in turn correlated with our own 40-yr clinical experience (M.M.L.). As a potential target, muscle tissue remains an "infrequent soil" for metastasis because of its unique mechanical and metabolic qualities.

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mentioning

confidence: 99%

Paucity of Muscle Metastasis in Otherwise Widely Disseminated Cancer

LaBan¹,

Nagarajan²,

Riutta³

2010

American Journal of Physical Medicine &Amp; Rehabilitation

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“…Skeletal muscle metastasis generally manifests itself as a “painful mass”, but it may be an incidental finding in imaging studies in patients without symptoms [ 5 , 14 ]. Sometimes, as in our case, it is the initial presentation of an undiagnosed primary tumor, with or without any other detectable metastases [ 1 , 2 , 5 , 15 ].…”

Section: Discussionmentioning

confidence: 93%

Skeletal Muscle Metastases as Initial Presentation of Gastric Carcinoma

et al. 2014

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Patient: Male, 67Final Diagnosis: Metastatic gastric carcinomaSymptoms: Painful swelling of soft tissueMedication: Folinic acid • fluouracil • irinotecanClinical Procedure: Radiological-pathological work-upSpecialty: OncologyObjective:Rare diseaseBackground:Gastric carcinoma is one of the most common malignancies in the world. Skeletal muscle metastases from gastric carcinoma are rare.Case Report:We report a case of a 67-year-old man patient with skeletal muscle metastasis developing from gastric carcinoma. He had a painful swelling of the left thigh. A chest computed tomography (CT) scan with enhancement showed pulmonary thromboembolism. Despite heparin therapy, edema and pain of the lower limbs increased bilaterally, so the patient underwent pelvic magnetic resonance imaging (MRI), which documented an altered signal intensity in the upper third of his thighs bilaterally. Furthermore, the examination of the ultrasound (US)-guided biopsy specimen of the left gluteal muscle showed signet ring cell adenocarcinoma metastasis. An upper gastrointestinal tract endoscopy confirmed a gastric ulceration, with a biopsy positive for signet ring cell adenocarcinoma. Because of the advanced stage of disease, the patient underwent only supportive care and died 74 days after admission.Conclusions:Skeletal muscle metastasis may be the initial presentation of gastric carcinoma and diagnosis could be difficult. Biopsy is mandatory for diagnosis.

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“…From a physiological perspective, it is difficult to explain why skeletal muscle is only rarely affected by metastatic seeding from hematogenous dissemination given its high vascularity and total mass accounting for nearly 50% of total body weight [8, 10]. It is hypothesized that dynamic variability in muscular blood flow, mechanical movement during active exercise and endogenous production of lactic acid may act as protective measures against said outcomes [7, 14–15].…”

Section: Discussionmentioning

confidence: 99%

“…Only 30 cases of muscle involvement from a gastric primary have been reported in the literature since the 1960s (Table 1) [7–11, 15–37]. The vast majority of patients in these reports are males ( n = 19, 63%) with females accounting only for 27% of cases ( n = 8).…”

Section: Discussionmentioning

confidence: 99%

Metastatic involvement of skeletal muscle from gastric adenocarcinoma

Aguirre

Salcedo

Zuquello

et al. 2019

Oxford Medical Case Reports

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Gastric cancer represents the fifth most common cancer diagnosis worldwide and the third leading cause of cancer-related mortality. In the USA, the overall 5-year survival rate is 31%, with distant disease nearing 5%. The most common sites of metastasis are the liver and peritoneum. Skeletal muscle involvement has been rarely reported. Since clinical and imaging findings overlap with primary sarcomas, a confirmatory biopsy is required for diagnosis. Prognosis remains poor with treatment options including palliative chemotherapy, radiotherapy and surgical resection. We report the case of a 57-year-old female presenting with extensive involvement of skeletal muscle 10 years after achieving remission. In addition to illustrating the refractoriness and poor outcomes associated with muscle involvement, this case and comprehensive review of the literature highlights important characteristics of disease biology and tumor genomics that warrant detailed discussion and exposition to a wider audience.

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An Elderly Patient with Gastric Carcinoma Developing Multiple Metastasis in Skeletal Muscle.

Cited by 17 publications

References 8 publications

Paucity of Muscle Metastasis in Otherwise Widely Disseminated Cancer

Paucity of Muscle Metastasis in Otherwise Widely Disseminated Cancer

Skeletal Muscle Metastases as Initial Presentation of Gastric Carcinoma

Metastatic involvement of skeletal muscle from gastric adenocarcinoma

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