An electrical impedance index to distinguish between normal and cancerous tissues

Blad, Börje; Wendel, P; Jönsson, Marcus; Lindström, Kjell

doi:10.1080/030919099294294

Cited by 33 publications

(22 citation statements)

References 6 publications

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“…Modulated electrohyperthermia (mEHT) is a non-invasive local technique using capacitive coupled 13.56-MHz radiofrequency for targeted destruction of tumor cells (Andocs et al 2009a) based on the elevated conductivity, permittivity, and current density in cancer compared to normal tissue (Andocs et al 2009b;Blad and Baldetorp 1996;Blad et al 1999;Fiorentini and Szasz 2006;Zou and Guo 2003). We have previously revealed that mEHT at <42°C can dominantly induce a caspase-independent programmed cell death in HT29 colorectal cancer xenografts as a result of cell stress synergistically induced by the electric field and heat (Andocs et al 2009a;Meggyeshazi et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia

Andócs

Meggyesházi

Balogh

et al. 2015

Cell Stress and Chaperones

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In modulated electrohyperthermia (mEHT) the enrichment of electric field and the concomitant heat can selectively induce cell death in malignant tumors as a result of elevated glycolysis, lactate production (Warburg effect), and reduced electric impedance in cancer compared to normal tissues. Earlier, we showed in HT29 colorectal cancer xenografts that the mEHTprovoked programmed cell death was dominantly caspase independent and driven by apoptosis inducing factor activation. Using this model here, we studied the mEHT-related cell stress 0-, 1-, 4-, 8-, 14-, 24-, 48-, 72-, 120-, 168-and 216-h post-treatment by focusing on damage-associated molecular pattern (DAMP) signals.

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Section: Introductionmentioning

confidence: 99%

Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia

Andócs

Meggyesházi

Balogh

et al. 2015

Cell Stress and Chaperones

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“…It has also been previously shown that the electrical properties of cancerous tissue differ from those of normal tissue. 4,9 Specifically within the prostate areas of prostate cancer had higher impedance than areas of normal tissue. 4 Distinguishing cancerous from normal tissue using the Smart Needle system may be beneficial for diagnostic and therapeutic management of renal malignancy and malignancy in other organs.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Bio-Impedance With a Smart Needle to Confirm Percutaneous Kidney Access

Hernandez¹,

Sinkov²,

Roberts³

et al. 2001

The Journal of Urology

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Purpose: The traditional method of percutaneous renal access requires freehand needle placement guided by C-arm fluoroscopy, ultrasonography, or computerized tomography. This approach provides limited objective means for verifying successful access. We developed an impedance based percutaneous Smart Needle system and successfully used it to confirm collecting system access in ex vivo porcine kidneys.Materials and Methods: The Smart Needle consists of a modified 18 gauge percutaneous access needle with the inner stylet electrically insulated from the outer sheath. Impedance is measured between the exposed stylet tip and sheath using Model 4275 LCR meter (Hewlett-Packard, Sunnyvale, California). An ex vivo porcine kidney was distended by continuous gravity infusion of 100 cm. water saline from a catheter passed through the parenchyma into the collecting system. The Smart Needle was gradually inserted into the kidney to measure depth precisely using a robotic needle placement system, while impedance was measured continuously.Results: The Smart Needle was inserted 4 times in each of 4 kidneys. When the needle penetrated the distended collecting system in 11 of 16 attempts, a characteristic sharp drop in resistivity was noted from 1.9 to 1.1 ohm m. Entry into the collecting system was confirmed by removing the stylet and observing fluid flow from the sheath. This characteristic impedance change was observed only at successful entry into the collecting system.Conclusions: A characteristic sharp drop in impedance signifies successful entry into the collecting system. The Smart Needle system may prove useful for percutaneous kidney access.

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“…Although the fact that an increased conductivity may be used to identify the presence of tumors [43,44], there are lots of limitations for BIA metric analysis due to the complication and variation in the biological system [45]. Their important review by author Damijan et al [19] discussed efficiently lots of problems in the biological concern.…”

Section: Physiological Parameters Affecting Bioelectrical Impedance Amentioning

confidence: 99%

Bioelectrical Impedance as a Diagnostic Factor in the Clinical Practice and Prognostic Factor for Survival in Cancer Patients: Prediction, Accuracy and Reliability

Tuorkey¹

2012

J Biosens Bioelectron

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Bioimpedance analysis could provide a clear figure about changes in cells and tissues based on frequencydependent changes, due to their electrical resistances for the applied electrical current. This review explains the physical principle of bioimpedance. And to monitor the progression of radiation induced tissue injury, particularly in radiotherapies. The interaction of radiation with the biological tissues and a prediction for their earlier and later alterations due to exposure are discussed. As well as, an overview for tissue identification by bioelectrical impedance analysis (BIA) is proposed. Bioimpedance analysis "applications and its limitations" in the health care, clinical practice and prognosis of overall survival in cancer patients are discussed.

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An electrical impedance index to distinguish between normal and cancerous tissues

Cited by 33 publications

References 6 publications

Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia

Upregulation of heat shock proteins and the promotion of damage-associated molecular pattern signals in a colorectal cancer model by modulated electrohyperthermia

Measurement of Bio-Impedance With a Smart Needle to Confirm Percutaneous Kidney Access

Bioelectrical Impedance as a Diagnostic Factor in the Clinical Practice and Prognostic Factor for Survival in Cancer Patients: Prediction, Accuracy and Reliability

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