An Electrochemical Approach for the Selective Detection of Cancer Metabolic Creatine Biomarker with Porous Nano-Formulated CMNO Materials Decorated Glassy Carbon Electrode

Abstract

The facile wet-chemical technique was used to prepare the low-dimensional nano-formulated porous mixed metal oxide nanomaterials (CuO.Mn2O3.NiO; CMNO NMs) in an alkaline medium at low temperature. Detailed structural, morphological, crystalline, and functional characterization of CMNO NMs were performed by X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-vis), Fourier-transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), and energy-dispersive X-ray spectroscopy (EDS) analyses. An efficient and selective creatine (CA) sensor probe was fabricated by using CMNO NMs decorated onto glassy carbon electrode (GCE) as CMNO NMs/GCE by using Nafion adhesive (5% suspension in ethanol). The relation of current versus the concentration of CA was plotted to draw a calibration curve of the CMNO NMs/GCE sensor probe, which was found to have a very linear value (r2 = 0.9995) over a large dynamic range (LDR: 0.1 nM~0.1 mM) for selective CA detection. The slope of LDR by considering the active surface area of GCE (0.0316 cm2) was applied to estimate the sensor sensitivity (14.6308 µAµM−1 cm−2). Moreover, the detection limit (21.63 ± 0.05 pM) of CMNO MNs modified GCE was calculated from the signal/noise (S/N) ratio at 3. As a CA sensor probe, it exhibited long-term stability, good reproducibility, and fast response time in the detection of CA by electrochemical approach. Therefore, this research technique is introduced as a promising platform to develop an efficient sensor probe for cancer metabolic biomarker by using nano-formulated mixed metal oxides for biochemical as well as biomedical research for the safety of health care fields.

Assessment of Melamine in Different Water Samples with ZnO‐doped Co3O4Nanoparticles on a Glassy Carbon Electrode by Differential Pulse Voltammetry

“…The metal oxides belong to semiconductor group are performed as the most potential electrons sensing substrate to the development of an electrochemical sensor for analyzing various chemicals and biochemical. Therefore, CuO/Mn 2 O 3 /NiO, [20] ZnO/MgO/Cr 2 O 3 nanofiber (NF), [21] and RuO 2 /ZnO/TiO 2 nanocomposites [22] are the ternary combination of semi‐conductive metal oxides and reported as reliable sensing substrates in the development of electrochemical sensors. ZnO is widely used semi‐conductor and fascinated to researchers due to its promising electrochemical properties, non‐toxic in nature, good stability with amazing photo‐sensitivity, excellent electron communication capacity.…”

Using High-Frequency Information and RH to Estimate AQI Based on SVR

“…It is divided into six categories (as shown in Table 1 ), which indicate the impact of air quality on health [ 2 ]. To measure AQI, the instrument first detects the concentration of pollutants, such as PM 2.5 , PM 10 , NO 2 , O 3 , SO 2 , and CO [ 3 , 4 ]. The impact of these pollutants on the human body is calculated as a sub-indicator.…”