An Electrochemical Aptasensor Integrating Zeolitic Imidazolate Framework for Highly Selective Detection of Bioaerosols

Abstract

Bioaerosols are the biological materials in the air, which may cause a continuous threat to human health. However, there are many challenges in monitoring bioaerosols such as lack of sensitivity and selectivity. Herein, we synthesized a series of nanohybrids containing zeolitic imidazolate frameworks (ZIFs) and covalent organic frameworks (COFs) to construct an electrochemical aptasensor for detecting adenosine triphosphate (ATP), a biomarker for bioaerosols. The synthesized nanohybrids can not only improve the selectivity of aptasensor because of the original crystal and chemical features of ZIF-67, but also boost its sensitivity due to the excellent conductivity of COFs. After optimizing the nanohybrids, the novel developed sensing platform achieved highly selective detection of ATP with an excellent detection limit of 0.11 nM in a wide linear range from 0.1 nM to 100 nM. Furthermore, this assay was applied to detect bioaerosols in real air samples, and the result showed a positive correlation with that of the culturing-based method, suggesting its potential applicability.

Sustainable Zeolite–Silver Nanocomposites via Green Methods for Water Contaminant Mitigation and Modeling Approaches

“…On the one hand, Zeolites are aluminosilicates with crystalline microporous structures, extensively utilized as catalysts, adsorbents, and ion exchangers [16][17][18][19][20]. They are classified as tectosilicate-type minerals and, due to their specific pore sizes, thermal stability, and high disponibility, the zeolites offer an excellent alternative for water remediation.…”

Functional COFs for Electrochemical Sensing: From Design Principles to Analytical Applications

“…the selectivity of aptasensor because of the original crystal and chemical features of ZIF-67, and boost the sensitivity due to the excellent conductivity of COFs[331] [a] Abbreviations: ABH, 4-aminobenzohydrazide; AO, amidoxime; 4-AP, 4-aminophenol; ATP, adenosine triphosphate; BPy, 5,5'-diamino-2,2'-bipyridine; CA, cyanuric acid; CC, catechol;CoPC-TA, tetraaminophthalocyanine-cobalt; DAT,3,5diamino-1,2,4-triazole; DB, diaminobenzene; DBD, 4,4'-diaminobiphenyl-2,2'-dicarboxylic acid; DBpX, α, α'-dibromo-p-xylen; DES, diethylstilbestrol; DETH, 2,5-diethoxyterephthalohydrazide; DHTA, 2,5-dihydroxyl-terephthalaldehyde; DPA, polydopamine; DPASV, differential pulse anodic stripping voltammetry; 2HP6, dihydroxylatopillar[6]arene; HT, 1-hexanethiol; HuNoV, human norovirus; MGCE, magnetic GCE; ONP, o-nitrophenol; PNP, p-nitrophenol; POX, paraoxon; RC, resorcinol; SMX, sulfamethoxazole; SPE, screen-printing electrode; TANM, tetra(4-anilyl)methane; TD, terephthaloyl dihydrazide ; TDBA, tripolycyanamide; TFB, 1,3,5-triformylbenzene; TFPOT, 2,4,6-tris-(4-formylphenoxy)-1,3,5-triazine; TPP, 1, 3, 6, 8-tetraphenylpyrene. [b] In unit of pM unless otherwise specified, # fg mL À Applications of COFs-based electrochemical sensors in food analysis.…”