An electrochemical biosensor based on AuNPs/Ti3C2 MXene three-dimensional nanocomposite for microRNA-155 detection by exonuclease III-aided cascade target recycling

Yang, Xiaoqi; Feng, Minghui; Xia, Jianfei; Zhang, Feifei; Wang, Zonghua

doi:10.1016/j.jelechem.2020.114669

Cited by 68 publications

(30 citation statements)

References 36 publications

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“…10 Due to their excellent electrical conductivity properties, MXenes were initially studied as energy storage materials for lithium-ion batteries [11][12][13][14][15][16][17] and supercapacitors. [18][19][20][21][22][23] In the past few years, MXenes have been explored and studied for use in many other applications, such as in electronics, [24][25][26][27] biomedicine, 28,29 sensors, [30][31][32][33][34][35][36][37] biosensors, [38][39][40][41][42][43][44] photothermal conversion, [45][46][47] water purification, [48][49][50][51] and even in the field of catalysis. [52][53][54][55][56][57]…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review of MXenes as catalyst supports for the oxygen reduction reaction in fuel cells

et al. 2021

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The oxygen reduction reaction (ORR) that occurs in the cathode of fuel cells is a major issue in proton exchange membrane fuel cells (PEMFCs) due to their sluggish kinetics. Exploring suitable materials for use as cathode catalysts can be challenging because the materials should be chemically active yet must be stable in an extremely corrosive environment in fuel cells. Since the successful introduction of graphene, 2-dimensional (2D) materials have received extensive research interest regarding their use as support materials for cathode catalysts due to their large surface area for catalyst dispersion. Recently, research on 2D MXene-based catalyst supports has started to increase. Excellent electronic properties, electrical conductivity, hydrophilicity and chemical and thermal stability are the key properties of potential MXenes used as catalyst supports. Therefore, in this review, the properties and performance of 2D MXene-based catalyst supports in the ORR are comprehensively discussed. This finding provides the groundwork for the exploration of MXenes in electrocatalysis, especially in the ORR. Challenges and future research directions are also discussed in this review.

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Section: Introductionmentioning

confidence: 99%

A comprehensive review of MXenes as catalyst supports for the oxygen reduction reaction in fuel cells

et al. 2021

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“…Besides, Wang, H. Y. et al [69] fabricated a competitive cDNAÀ Fc/MXene/Apt/Au/GCE aptasensor based on a cDNAÀ Fc/MXene probe to detect the breast cancer marker Mucin1 (MUC1). When the detection was con- There were also some other aptasensors based on MXene, such as MoS 2 @Ti 3 C 2 T x MXene hybrid-based one for sensitive and rapid quantification of thyroxine (T4) [71], AuNPs/Ti 3 C 2 MXene three-dimensional nanocomposite based one for for sensitive miRNA-155 detection [67], and Prussian Blue (PB)/Ti 3 C 2 hybrid based one for exosomes detection [70]. They are all listed in the Table 2.…”

Section: Aptasensorsmentioning

confidence: 99%

Application of MXene in Electrochemical Sensors: A Review

Sun

et al. 2021

Electroanalysis

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Electroanalysis has obtained considerable progress over the past few years, especially in the field of electrochemical sensors. Broadly speaking, electrochemical sensors include not only conventional electrochemical biosensors or non‐biosensors, but also emerging electrochemiluminescence (ECL) sensors and photoelectrochemical (PEC) sensors which are both combined with optical methods. In addition, various electrochemical sensing devices have been developed for practical purposes, such as multiplexed simultaneous detection of disease‐related biomarkers and non‐invasive body fluid monitoring. For the further performance improvement of electrochemical sensors, material is crucial. Recent years, a kind of two‐dimensional (2D) nanomaterial MXene containing transition metal carbides, nitrides and carbonitrides, with unique structural, mechanical, electronic, optical, and thermal properties, have attracted a lot of attention form analytical chemists, and widely applied in electrochemical sensors. Here, we reviewed electrochemical sensors based on MXene from Nov. 2014 (when the first work about electrochemical sensor based on MXene published) to Mar. 2021, dividing them into different types as electrochemical biosensors, electrochemical non‐biosensors, electrochemiluminescence sensors, photoelectrochemical sensors and flexible sensors. We believe this review will be of help to those who want to design or develop electrochemical sensors based on MXene, hoping new inspirations could be sparked.

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“…In addition to this example, a three-dimensional Au nanoparticle and MXene (Ti 3 C 2 ) nanocomposite was developed for use as an electrochemical miRNA-155 biosensor [ 63 ]. The developed Au nanoparticle and MXene nanocomposite could facilitate redox signals from the methylene blue used as the redox probe in this research, thereby achieving high sensitivity (detection limit: 0.35 fM, linear response ranges from 1.0 fM to 10 nM).…”

Section: Mxene-based Electrochemical Biosensorsmentioning

confidence: 99%

“…This biosensor had a low assay time of 80 min and exhibited fourfold higher electrochemical signal than biosensors prepared without the MXene (detection sensitivity of 204 aM and 138 aM for miR-21 and miR-141 detection, respectively). In addition to this example, a three-dimensional Au nanoparticle and MXene (Ti 3 C 2 ) nanocomposite was developed for use as an electrochemical miRNA-155 biosensor [63]. The developed Au nanoparticle and MXene nanocomposite could facilitate redox signals from the methylene blue used as the redox probe in this research, thereby achieving high sensitivity (detection limit: 0.35 fM, linear response ranges from 1.0 fM to 10 nM).…”

Section: Mxene-based Electrochemical Biosensorsmentioning

confidence: 99%

Recent Advances in MXene Nanocomposite-Based Biosensors

et al. 2020

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The development of advanced biosensors with high sensitivity and selectivity is one of the most demanded concerns in the field of biosensors. To meet this requirement, up until now, numerous nanomaterials have been introduced to develop biosensors for achieving high sensitivity and selectivity. Among the latest nanomaterials attracting attention, MXene is one of the best materials for the development of biosensors because of its various superior properties. MXenes are two-dimensional inorganic compounds with few atomic layers that possess excellent characteristics including high conductivity and superior fluorescent, optical, and plasmonic properties. In this review, advanced biosensors developed on the basis of the MXene nanocomposite are discussed with the selective overview of recently reported studies. For this, introduction of the MXene including the definition, synthesis methods, and its properties are discussed. Next, MXene-based electrochemical biosensors and MXene-based fluorescent/optical biosensors are provided, which are developed on the basis of the exceptional properties of the MXene nanocomposite. This review will suggest the direction for use of the Mxene nanocomposite to develop advanced biosensors with high sensitivity and selectivity.

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An electrochemical biosensor based on AuNPs/Ti3C2 MXene three-dimensional nanocomposite for microRNA-155 detection by exonuclease III-aided cascade target recycling

Cited by 68 publications

References 36 publications

A comprehensive review of MXenes as catalyst supports for the oxygen reduction reaction in fuel cells

A comprehensive review of MXenes as catalyst supports for the oxygen reduction reaction in fuel cells

Application of MXene in Electrochemical Sensors: A Review

Recent Advances in MXene Nanocomposite-Based Biosensors

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