An electrochemical chiral sensor based on competitive host–guest interaction for the discrimination of electroinactive amino acids

Abstract

A novel electrochemical chiral sensor was designed based on the principle of competitive host-guest interaction and utilized for the discrimination of electroinactive proline (Pro) isomers. Electroactive methylene blue (MB) was...

Construction of a Dual-Mode Biosensor with Ferrocene as Both a Signal Enhancer and a Signal Tracer for Electrochemiluminescent and Electrochemical Enantioselective Recognition

“…The practicability of the developed chiral sensor is evaluated by the quantitative analysis of His isomers in the mixture. 4 We measured the ECL (Figure S8A) and DPV signals (Figure S8C) of Fc/β-CD/ZnIn 2 S 4 /GCE incubated with the mixture of different chirality containing different amounts of L-His. Both the ECL intensity and oxidation peak current of Fc decrease with the increase in L-His percentage from 0 to 100%.…”

“…Chiral electroanalysis is an efficient technique for the identification of l - and d -isomers, with the distinct merits of easy operation and rapid analysis. − Similar to spectroscopic techniques that require chromophoric groups, chiral electroanalysis needs electroactive units for the generation of electrochemical signals by themselves. However, it is difficult to electroanalyze chiral drugs because majority of them cannot offer electrochemical signals . To detect nonelectroactive chiral compounds, it is necessary to explore proper mediators to facilitate electron transfer for the achievement of chiral electroanalysis.…”

An electrochemical sensor based on metal–organic framework–chiral ionic liquid composites for the enantiorecognition of tryptophan enantiomers

“…[8][9][10][11][12] In recent years, electrochemical sensors have attracted extensive attention from researchers for their high sensitivity, strong selectivity, fast response rate, low professional operation requirements, and portability. Moreover, polysaccharides, [13][14][15][16][17][18] chiral polyaniline-twisted nanoribbon, 19 chiral ionic liquid 20 and other chiral recognition materials have been used to construct chiral electrochemical sensors for the chiral recognition of Trp enantiomers.…”

A surface molecularly imprinted electrochemical biosensor for the detection of SARS-CoV-2 spike protein by using Cu7S4-Au as built-in probe

“…Electron transfer mediators such as K 3 [Fe(CN) 6 ] [18] , methylene blue (MB) [19] , and toluidine blue (TB) [20] are commonly used as the signal indicators in electrochemical biosensors. Recently, copper sulfide (Cu x S y ) nanocrystallites have attracted considerable attention as the signal probe for bioanalysis due to their high electrical conductivity, hypotoxicity, and peroxidase-mimicking activity [21] , [22] .…”