2015
DOI: 10.1016/j.bios.2014.07.017
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An electrochemical immunosensor for ultrasensitive detection of carbohydrate antigen 199 based on Au@Cu x OS yolk–shell nanostructures with porous shells as labels

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Cited by 60 publications
(26 citation statements)
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“…To quantify the amount of captured biomarkers, another biomarker-recognizing molecule labeled with a reporter is added to the system. 32 In another example, a sandwich assay was used with an ionic liquid functionalized graphene electrode to sensitively detect a cancer biomarker CA15-3 by square wave voltammetry (SWV). In order to increase sensitivity, enzymes such as glucose oxidase (GOx) and horseradish peroxidase (HRP) are generally used as reporters (Fig.…”
Section: Electrochemical Methodsmentioning
confidence: 99%
“…To quantify the amount of captured biomarkers, another biomarker-recognizing molecule labeled with a reporter is added to the system. 32 In another example, a sandwich assay was used with an ionic liquid functionalized graphene electrode to sensitively detect a cancer biomarker CA15-3 by square wave voltammetry (SWV). In order to increase sensitivity, enzymes such as glucose oxidase (GOx) and horseradish peroxidase (HRP) are generally used as reporters (Fig.…”
Section: Electrochemical Methodsmentioning
confidence: 99%
“…Electrochemical impedance spectroscopy (EIS) was employed to monitor the interface properties of the carbon electrode surface during stepwise modifications [27][28][29]. Different stages of the modified electrode were characterized in the test base solution containing 0.1 mM KCl and 5.0 mM [Fe(CN 6 )] 3-/ 4-.…”
Section: Eis Characterizationmentioning
confidence: 99%
“…(3,43) Thereinto, the edge-effect sites could realize fast electron-transfer kinetics; (32) the emerging chemical moieties, either hydrophilic or hydrophobic, would not only effectively prevent the aggregation of graphene sheets by strong polar-polar interactions or by their bulky size (43) but also facilitate various functionalizations to enhance the biosensor performance. (44) In contrast, expitaxial growth by chemical vapor deposition on trasition metals and unzipping of carbon nanotubes may produce graphene with metallic impurities; (45) the remaining methods may decrease the catalytic reactivity of graphene owing to its large size. Therefore, the graphene synthesized by the RGO process is advantageous for electrochemical applications compared with those synthesized by the other methods.…”
Section: Graphene Synthesismentioning
confidence: 99%
“…The as-prepared biosensor showed a high selectivity to Hg 2+ and a low detection limit of 5 nM. Guo et al (44) designed an electrochemical immunosensor to detect carbohydrate antigen 199 on the basis of antibody-antigen interactions. Xu et al (58) used the inhibitory effect between an enzyme and its analyte to construct a biosensor that selectively detects Forchlorfenuron.…”
Section: Introduction Of Biosensor and Electrochemical Biosensormentioning
confidence: 99%
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