An electrochemical molecularly imprinted microfluidic paper-based chip for detection of inflammatory biomarkers IL-6 and PCT

Li, Wenpeng; Xiang, Jiawen; Han, Jinglong; Man, Mingsan; Chen, Lingxin; Li, Bowei

doi:10.1039/d3an01367g

Analyst

2023

DOI: 10.1039/d3an01367g

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An electrochemical molecularly imprinted microfluidic paper-based chip for detection of inflammatory biomarkers IL-6 and PCT

Wenpeng Li,

Jiawen Xiang,

Jinglong Han

et al.

Abstract: Based on surface biomolecular imprinting technology, a rotary microfluidic electrochemical paper-based chip (MIP-ePADs) was proposed for sensitive and selective detection of human interleukin 6 (IL-6) and procalcitonin (PCT).

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Cited by 4 publications

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Colorimetric detection of glucose in food using gold nanoparticles as nanoenzymes combined with a portable smartphone-assisted microfluidic paper-based analysis device

Chen,

Guan

2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Colorimetric detection of glucose in food using gold nanoparticles as nanoenzymes combined with a portable smartphone-assisted microfluidic paper-based analysis device

Chen,

Guan

2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Molecularly imprinted polymer sensors for biomarker detection in cardiovascular diseases

Tang,

Han,

Zhang

et al. 2024

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Ratiometric Electrochemical Detection of Interleukin-6 Using Electropolymerized Methylene Blue and a Multi-Walled Carbon-Nanotube-Modified Screen-Printed Carbon Electrode

Liu,

Wang

et al. 2024

Biosensors

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Herein, we report a ratio-based electrochemical biosensor for the detection of interleukin-6 (IL-6). We electropolymerized methylene blue (MB) on the surface of screen-printed carbon electrodes; introduced an internal reference signal probe; modified the carboxylate multi-walled carbon nanotubes on the electrode surface to increase the electrochemically active area; and finally linked the amino-modified IL-6 aptamer to the electrode surface through the Schiff base reaction, with bovine serum albumin (BSA) added to mask non-specific adsorption. After adding IL-6 to the samples, the signal of IMB remained almost unchanged, while the signal of I[Fe(CN)6]3−/4− decreased with increasing IL-6 concentration. Thus, a novel ratiometric electrochemical sensor with a linear range of 0.001~1000.0 ng/mL and a low detection limit of 0.54 pg/mL was successfully developed. The sensor had high repeatability, stability, sensitivity, and practicability. It provides a new method for constructing proportional electrochemical sensors and detecting IL-6.

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An electrochemical molecularly imprinted microfluidic paper-based chip for detection of inflammatory biomarkers IL-6 and PCT

Abstract: Based on surface biomolecular imprinting technology, a rotary microfluidic electrochemical paper-based chip (MIP-ePADs) was proposed for sensitive and selective detection of human interleukin 6 (IL-6) and procalcitonin (PCT).

Cited by 4 publications

References 36 publications

Colorimetric detection of glucose in food using gold nanoparticles as nanoenzymes combined with a portable smartphone-assisted microfluidic paper-based analysis device

Colorimetric detection of glucose in food using gold nanoparticles as nanoenzymes combined with a portable smartphone-assisted microfluidic paper-based analysis device

Molecularly imprinted polymer sensors for biomarker detection in cardiovascular diseases

Ratiometric Electrochemical Detection of Interleukin-6 Using Electropolymerized Methylene Blue and a Multi-Walled Carbon-Nanotube-Modified Screen-Printed Carbon Electrode

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