An electrochemical sensing method for the determination of levodopa using a poly(4-methyl-ortho-phenylenediamine)/MWNT modified GC electrode

Kamyabi, Mohammad Ali; Rahmanian, Najmeh

doi:10.1039/c4ay01638f

Cited by 26 publications

(12 citation statements)

References 46 publications

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“…The oxidation peak occurs at the potential 512 mV (scan rate 100 mVs −1 ) and corresponds to the oxidation of levodopa to dopaquinone. The reduction peak which occurs at the potential 488 mV (scan rate 100 mVs −1 ) corresponds to the reverse reaction (reduction of dopaquinone to levodopa) [ 12 , 17 ]. The influence of scan rate on LSV voltammograms is also visible in Figure 4 —the higher the value of scan rate was, the higher levodopa peak current was.…”

Section: Resultsmentioning

confidence: 99%

“…The use of fluorescence spectrometry [ 7 ] and spectrophotometry [ 8 ] was also reported. Voltammetry which belongs to the group of electrochemical methods is also a useful tool for Levodopa determination [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ]. In comparison to the mentioned methods, voltammetry has many advantages.…”

Section: Introductionmentioning

confidence: 99%

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Highly Sensitive Levodopa Determination by Means of Adsorptive Stripping Voltammetry on Ruthenium Dioxide-Carbon Black-Nafion Modified Glassy Carbon Electrode

Górska

Paczosa‐Bator

Piech

2020

Sensors

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A new, highly sensitive Adsorptive Stripping Voltammetric method for levodopa determination was developed. As a working electrode, the glassy carbon electrode (GCE) modified with carbon black (CB), RuO2·xH2O (RuO2) and Nafion was used (CB-RuO2-Nafion GCE). Levodopa signal obtained on the modified electrode was 12 times higher compared to GCE. During research, instrumental parameters were optimized: sampling time ts = 10 ms, waiting time tw = 10 ms, step potential Es = 5 mV and pulse amplitude ΔE = 50 mV. Preconcentration potential Eprec was equal to 0 mV. The best results were obtained in 0.025 M perchloric acid (approx. pH 1.4). Signal repeatability measured on the CB-RuO2-Nafion modified electrode for 0.2 µM of levodopa was equal to 2.1% (levodopa concentration 1 µM, n = 5). Linearity of the method was achieved in the concentration range from 1 to 8 µM. Limit of detection was equal to 17 nM. Recoveries calculated for pharmaceutical products and tap water measurements were in the range 102–105%, which confirms the accuracy of the developed. The applicability of the method was confirmed by analysis of pharmaceutical products and tap water samples. Based on obtained results, it might be concluded that the developed voltammetric method could be a useful tool in routine drug analysis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Levodopa Determination by Means of Adsorptive Stripping Voltammetry on Ruthenium Dioxide-Carbon Black-Nafion Modified Glassy Carbon Electrode

Górska

Paczosa‐Bator

Piech

2020

Sensors

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show abstract

“…The linear equation could be expressed as Epa =−0.052 pH +0.6904 ( R 2 =0.95). This slope closed to the expected value of −0.059, indicating that an equal number of protons (2 H + ) accompanied the electron transfer (2 e − ) .…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Ferrosoferric Oxide‐graphene Oxide Nanocomposite by Isoelectric Point Method for the Detection of Catechol

Wang

Cheng

2019

Electroanalysis

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Ferrosoferric oxide functionalized graphene oxide nanocomposite with layer by layer structure was synthesized by isoelectric point method in this work. The prepared material was characterized by Fourier transform infrared spectroscopy, X‐ray diffraction, scanning electron microscopy, transmission electron microscopy and Raman spectroscopy. Then the material was used to modify a glassy carbon electrode to fabricate an electrochemical sensor for the detection of catechol. The electrochemical sensor exhibited excellent electrochemical performance towards the detection of catechol with a linear response in the range of 5–205 μM and a detection limit of 2.32 μM. Furthermore, the electrochemical sensor showed excellent selectivity, stability and repeatability. These results revealed ferrosoferric oxide functionalized graphene oxide nanocomposite has potential applications in the fabrication of electrochemical sensors.

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“…Differential pulse voltammetry (DPV) with high sensitivity and resolution was employed to efficiently analyze the L-dopa at low concentration (potential range: 0.0 to +0.5 V, amplitude: 50 mV, pH 6.0). 27,29 The anodic peak currents are linearly enhanced with the increasing concentration of L-dopa from 1.0 × 10 -6 to 1.2 × 10 -3 M (Fig. 6A).…”

Section: Electrochemical Detection Of L-dopamentioning

confidence: 97%

Highly Sensitive Electrochemical Sensing Platform for the Detection of L-dopa Based on Electropolymerizing Glutathione Disulfide and Multi-walled Carbon Nanotube-modified Electrodes

Yang¹,

Zhu²,

Ma³

et al. 2018

S.Afr.j.chem.

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A facile sensing platform for the detection of L-dopa has been developed by electropolymerizing glutathione disulfide (PGSSG) on the surface of glass carbon electrodes (GCE) which were modified by multi-walled carbon nanotubes (MWCNTs). The electrochemical behaviour of the proposed electrodes were investigated via cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The morphology of the PGSSG and PGSSG/MWCNTs were characterized by scanning electron microscopy (SEM). Under the optimized experimental conditions, the sensing platform showed the linear response to L-Dopa in a range from 1.0 × 10-6 to 1.2 × 10-3 M with a detection limit of 3.3 × 10-7 M (S/N = 3). Moreover, with the merits of high sensitivity and selectivity, good stability and reproducibility, the sensor was successfully applied for the determination of L-dopa in a real sample.

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An electrochemical sensing method for the determination of levodopa using a poly(4-methyl-ortho-phenylenediamine)/MWNT modified GC electrode

Abstract: DPVs of 0.08 mmol L−1l-Dopa and 1.2 mmol L−1 AA in PBS pH 7 at (A) before and (B) after modification of a GCE with poly (4-MoPD)/MWNTs in PBS pH 7, scan rate: 100 mV s−1.

Cited by 26 publications

References 46 publications

Highly Sensitive Levodopa Determination by Means of Adsorptive Stripping Voltammetry on Ruthenium Dioxide-Carbon Black-Nafion Modified Glassy Carbon Electrode

Highly Sensitive Levodopa Determination by Means of Adsorptive Stripping Voltammetry on Ruthenium Dioxide-Carbon Black-Nafion Modified Glassy Carbon Electrode

Synthesis of Ferrosoferric Oxide‐graphene Oxide Nanocomposite by Isoelectric Point Method for the Detection of Catechol

Highly Sensitive Electrochemical Sensing Platform for the Detection of L-dopa Based on Electropolymerizing Glutathione Disulfide and Multi-walled Carbon Nanotube-modified Electrodes

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