An electrochemical sensing platform based on a modified carbon paste electrode with graphene/Co3O4 nanocomposite for sensitive propranolol determination

Abstract

A simple and sensitive method for the determination of propranolol using a modified carbon paste electrode (CPE) with graphene/Co3O4 nanocomposite (Gr-Co3O4 NC/CPE) was presented. The electrochemical measurements of propranolol are studied using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CHA). The Gr-Co3O4 NC/CPE exhibits excellent catalytic activity towards the electrochemical oxidation of propranolol in phosphate buffer solution (PBS) of pH 7.0. The Gr-Co3O4 NC/CPE facilitates the determination of propranolol in the concentration range 1.0–300.0 μM and a detection limit and sensitivity of 0.3 μM. and 0.1275 μA/μM were achieved.

Chitosan-Based Electrochemical Sensors for Pharmaceuticals and Clinical Applications

“…Furthermore, these sensors are valuable in the detection of neoplastic markers for early disease diagnosis [42][43][44], such as aptasensors for detecting human epidermal growth factor receptor 2 proteins, a critical prognostic biomarker for breast cancer [43], or the nanosensor for detecting sarcosine, a biomarker for prostate cancer, using composite films of carbon nanotubes and CTS [44]. Moreover, the literature reports electrochemical sensors based on CTS for the detection of a wide range of pharmaceutical substances with various indications, such as paracetamol [45], diclofenac [46], clindamycin [47], metformin [48], propranolol [49], and fluoxetine [50], as well as a series of metabolites present in biological fluids, such as cholesterol [51], uric acid [52], xanthine, hypoxanthine, p53 protein, and purines, considered potential biomarkers [6]. CTS-based sensors have also been utilized for the detection of narcotics and their metabolites, such as cocaine [53], morphine [54], and methamphetamine [55].…”