An electrochemical sensing platform to determine tetrahydrozoline HCl in pure form, pharmaceutical formulation, and rabbit aqueous humor

Abstract

In pharmaceutical industry and clinical applications, finding real-time analyzers with minimal sample preparation is a good aim. The presented solid-contact sensor offers a reasonable tool for selective, sensitive and eco-friendly analysis.

Film-Based Electronic Volatile Acid Vapor Sensor with Ultrahigh Sensitivity for Real-Time Analysis

“…By using the equation, 3.3σ/ S , the LOD value was found to be 9 ppb, where σ and S are the relative standard deviation and slope of the calibration plot, respectively . Although several HCl sensors based on various transduction mechanisms, including electrochemical, opto-chemical, optical, and colorimetry, − are reported in the literature, vapor-phase detection of HCl based on an AC impedance study was found to be the infrequent one among the others. Thus, PVA-supported NDI-10 film emerges as an advanced polymeric composite sensor based on AC impedance with a low LOD for HCl vapors.…”

Anthelmintics for drug repurposing: Opportunities and challenges

“…Mebendazole and flubendazole, two members of BZDs, cause the loss of cytoplasmic microtubules of helminths, resulting in the loss of transport of secretory vesicles, a decrease in the uptake of glucose, and an increase in the use of stored glycogen ( Hamilton & Rath, 2017 ). The salicylanilides drugs, such as rafoxanide, oxyclozanide, and closantel, are proton ionophores ( Hamilton and Rath, 2017 , Hu et al, 2013 ) or proton carriers to help to transfer protons from the aqueous phase into the lipophilic membrane ( Mahmoud, Saad, Elzanfaly, Amer, & Essam, 2020 ). Other anthelmintics are functionally classified as nicotinic, glutamate-gated chloride channel potentiators, or macrolides ( Hamilton & Rath, 2017 ).…”

Design of screen-printed potentiometric platform for sensitive determination of mirabegron in spiked human plasma; molecular docking and transducer optimization

“…Although nanoparticles are not part of the direct electrode's sensing mechanism, they have been incorporated into the SPEs to offer higher signal, increase electrode stability, and eradicate the undesired water layer. Single-walled carbon nanotubes, 18 multiwall carbon nanotubes (MWCNT), 19 graphene, 20 and most recently gold nanoparticles (GNP) 17 are the most commonly used candidates. In the production of electrochemical sensors, GNP are known to be a suitable modifier for electrode surfaces.…”