An Electrochemical Sensor for Phenylephrine Based on Molecular Imprinting

Abstract

Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and cross-linking varied. When the ratio was 4:40, the surface morphology between the imprinted electrode (M-electrode) and the control electrode (N-electrode) became unambiguously different. This artificial receptor exhibited high selectivity for the template compared to closely related analogue. The response of the sensor varied in different concentration range might due to the heterogeneity of the MIPs membrane. This sensor was also used to determine phenylephrine in tablet samples.

Development of a New Coated Graphite Phenylephrine Potentiometric Sensor and Its Applications to Pharmaceutical and Biological Analysis

“…It should be noted that lack of internal solution and more mechanical stability are further advantages of the proposed CGE over the usual liquid membrane selective electrodes. Moreover, the linear range of the proposed CGE (3.0 10 À6 -5.6 10 À2 M) is also comparable with some of other PE determination methods such as spectrophotometry [9] or electrochemistry [14] which have linear range 9.8 10 …”

“…The requirement of rigorous control of PE concentration in pharmaceutical industry and also biological samples had led to the development of a variety of determination methods such as liquid and gas chromatography [4][5][6][7], spectrophotometry [8,9], spectrofluorimetry [10,11] and electrochemistry [12][13][14]. However, most of these methods are either time-consuming or require expensive and sophisticated instruments, well controlled experimental conditions and some sample pretreatments.…”

Biosensing Applications of Molecularly Imprinted Nanomaterials

“…An amperometric morphine sensor has been developed where the analyte morphine is selectively enriched on an MIP film and subsequently quantified by electrooxidation [117]. So far, the studies on the development of MIP-based sensors, in particularly electrochemical [88,89,[116][117][118][119][120][121][122][123][124][125][126] and optical [127][128][129][130][131][132][133][134][135][136][137] sensors, have been dramatically reported. At the same time, mass-sensitive transducers are increasing in popularity since the approach has the advantage, theoretically at least, that it can be universally applied to a broad range of targets [42,[138][139][140][141][142][143][144][145].…”

Preparation of Pb(II) Ion Imprinted Polymer and Its Application as the Interface of an Electrochemical Sensor for Trace Lead Determination

“…Methods for heavy metals determination mainly include optical analysis, such as flame/graphite furnace atomic absorption spectrometry, [5][6][7] inductively coupled plasma atomic emission spectrometry, 8 hydride generation atomic fluorescence spectrometry 9 and inductively coupled plasma mass spectrometry, 10 and electrical analysis like anodic stripping voltammetry via electrochemical sensor. 11,12 Compared with optical methods, electrochemical methods possess such advantages as low instrumental cost, portability, sufficient sensitivity, preconcentration function and low matrix interferences, which altogether makes it an extremely favorable technique.…”