An Electron Microscopic Study of the Effects of Hypervitaminosis a on the Maternal-Embryonic Relationship of the Rat at 8 Days of Pregnancy

Morriss, Gillian M.

doi:10.1530/jrf.0.0330451

Cited by 8 publications

References 8 publications

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Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea

Sadler

Cardell

1977

Anat. Rec.

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Developing neuroepithelial cells from the cranial region of neural folds were examined at various intervals from 15 minutes to four hours after administration of teratogenic (250 mg/kg) or embryolethal (500 mg/kg) doses of HU to ICR/DUB mice on ninth day of gestation. Thirty percent of surviving fetuses showed extencephaly after the teratogenic dose. The initial ultrastructural change in some neuroepithelial cells occurred within 15 minutes to one hour after treatment with the teratogenic dose and involved a breakdown of polyribosomes into monosomes which were dispersed evenly in the cytosome. At one to two hours, condensation of the cytoplasm and chromatin was observed along with distorted nuclear shape. At two to four hours, cells exhibited extremely condensed cytoplasm and fragmentation of the cells occurred. The affected cells showed pyknotic nuclei and segregation of fibrillar and granular components of the nucleolus. In some nuclei, particularly after treatment with the higher dose of HU, a condensation of the nucleolus was observed. At this stage images were obtained which indicated that neighboring cells phagocytosed the cellular fragments derived from the HU affected cells.

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Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea

Sadler

Cardell

1977

Anat. Rec.

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Maternal-Fetal Transfer of Vitamin A and Its Impact on Mammalian Embryonic Development

Quadro

Spiegler

2020

Subcellular Biochemistry

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Detection of neuroteratogens with an in vitro cytotoxicity assay using primary monolayers cultured from dissociated foetal rat brains

Khera¹,

Whalen²

1988

Toxicology in Vitro

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An Electron Microscopic Study of the Effects of Hypervitaminosis a on the Maternal-Embryonic Relationship of the Rat at 8 Days of Pregnancy

Cited by 8 publications

References 8 publications

Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea

Ultrastructural alterations in neuroepithelial cells of mouse embryos exposed to cytotoxic doses of hydroxyurea

Maternal-Fetal Transfer of Vitamin A and Its Impact on Mammalian Embryonic Development

Detection of neuroteratogens with an in vitro cytotoxicity assay using primary monolayers cultured from dissociated foetal rat brains

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