In this paper, a kind of antinarrowband interference intelligent method based on cognitive MIMO (multiple-input multiple-output) airspace, time domain, frequency domain, and code domain is proposed. This method combines perceptual technology, spread spectrum code, MIMO space-time coding, and so on. Through coordinating space, time, frequency, and code element diversity, the narrowband interference in the UAV (unmanned aerial vehicle) monitoring and control link is effectively countered. The input and output model of MIMO monitoring and control link of UAV with natural interference are described. Then, the realization principle of the multidomain antinarrowband interference method based on CR-MIMO is presented, and the corresponding models of receiving and transmitting are also given. Finally, the anti-interference performance of the proposed method is analyzed theoretically and validated through simulation experiments, and the effectiveness of the proposed method is verified.