An electrophysiological study of the postnatal development of the autonomic innervation of the rat submandibular salivary gland

Bottaro, Brian; Cutler, Leslie S.

doi:10.1016/0003-9969(84)90061-x

Cited by 36 publications

(17 citation statements)

References 16 publications

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“…In the parotid gland, development is slower, with secretion granules first appearing one day after birth (Redman and Sreebny, 1971 (Cutler and Rodan, 1976), and becomes progressively responsive to P-adrenergic stimuli between one and six days post partum, due to the increase in receptor density (Cutler et al, 1981). This increase was found to parallel the ingrowth of sympathetic nerve fibers during this time period, suggesting the stimulation of receptor production by the nerves (Bottaro and Cutler, 1984;Cutler et al, 1985). In vitro, there is isoproterenol-stimulated release of amylase and Bi-immunoreactive proteins (Bi-IP, see below) from the four-day submandibular gland (Ball and Nelson, 1978a;Ball and Redman, 1984), and of Bi-IP from the sublingual gland at five days (Ball et al, 1988a).…”

Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

179

171

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The major salivary glands of mammals are represented by three pairs of organs that cooperate functionally to produce saliva for the oral cavity. While each type of gland produces a signature secretion that complements the secretions from the other glands, there is also redundancy as evidenced by secretion of functionally similar and, in some cases, identical products in the three glands. This, along with their common late initiation of development, in fetal terms, their similarities in developmental pattern, and their proximate sites of origin, suggests that a common regulatory cascade may have been shared until shortly before the onset of overt gland development. Furthermore, occasional ectopic differentiation of individual mature secretory cells in the wrong" gland suggests that control mechanisms responsible for the distinctive cellular composition of each gland also share many common steps, with only minor differences providing the impetus for diversification. To begin to address this area, we examine here the origins of the salivary glands by reviewing the expression patterns of several genes with known morphogenetic potential that may be involved based on developmental timing and location. The possibility that factors leading to determination of the sites of mammalian salivary gland development might be homologous to the regulatory cascade leading to salivarv gland formation in Drosophila is also evaluated. In a subsequent section, cellular phenotypes of neonatal and adult glands are compared and evaluated for insights into the mechanisms and lineages leading to cellular diversification. Finally, the phenomena of proliferation, repair, and regeneration in adult salivary glands are reviewed, with emphasis on the extent to which the cellular diversity is reversible and which cell type other than stem cells has the ability to redifferentiate into other cell types.

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Section: (6) Origin Of the Three Major Types Of Salivary Glandsmentioning

confidence: 99%

Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

179

171

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“…The three major salivary glands of the rat are often used in research including autonomic regulation, the process of neuronal development in those glands, and histochemical studies of neurotransmitters and neuropeptides [1,8,13,37,45]. It is generally understood that the salivary secretion of the parotid gland (PG) which is composed almost entirely of serous acini and the submandibular gland (SMG) which is composed of a mixture of serous and mucous acini [31] are controlled by both the sympathetic and parasympathetic nervous systems, and secretion of the sublingual gland (SLG) which is composed of mainly mucous acini appears to be controlled by the parasympathetic nervous system alone [15,51,54].…”

Section: Introductionmentioning

confidence: 99%

Differences in Morphology and Neuropeptide Immunoreactivity of Superior Cervical Ganglion Neurons that Innervate the Major Salivary Glands in Rats.

Miyauchi

Asamoto

Nojyo

et al. 2001

Acta Histochem. Cytochem

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A neuronal tracer, WGA-HRP, was injected into the rat parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG) to label the superior cervical ganglion (SCG) neurons, and the number, size of soma, dendritic arborization and immunoreactivities (IR) of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were investigated. The number and size of neurons projecting into SMG were greater than those of neurons projecting into the PG or SLG. The PG and SLG projecting neurons did not show significant differences in their number and size of soma, even the weight of the SLG was much smaller than the other two glands. The total length of dendrites of the SMG projecting neurons was greater than those of the PG or SLG projecting neurons. PG and SLG projecting neurons showed no significant difference in the total length of their dendrites. PG and SLG projecting neurons with NPY-IR were larger in number than SMG projecting neurons. SLG projecting neurons with VIP-IR were greater in number than neurons projecting into the other two glands. Our results indicate the differences in morphology and neuropeptide immunoreactivities among the SCG neurons which may be due to the differences in the neuronal functions and the participation of neurotrophic factors.

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“…The density of cholinergic receptors per gland tissue was reported to be rapidly increased during the first 2 weeks and reached adult levels by 3 weeks of age (Bylund et al 1982). However, electrical stimulation of the postganglionic parasympathetic nerve at birth caused a watery secretion from the developing duct system, while stimulation of the sympathetic nerve did not cause protein secretion from the developing duct or acini (Bottaro & Cutler, 1984). On the other hand, the elimination of excessive preganglionic fibres arising from the superior salivatory neurones to innervate individual submandibular ganglion cells occurs mainly during the first two weeks after birth, and each ganglion cell is subsequently contacted by a single preganglionic fibre after about 5 weeks (Lichtman, 1977).…”

Section: Discussionmentioning

confidence: 99%

Two types of parasympathetic preganglionic neurones in the superior salivatory nucleus characterized electrophysiologically in slice preparations of neonatal rats

Matsuo

Kang

1998

The Journal of Physiology

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The electrophysiological properties of parasympathetic preganglionic neurones in the superior salivatory nucleus were studied in thin‐ and thick‐slice preparations of rats aged 1 and 2 weeks using the whole‐cell patch‐clamp technique. The superior salivatory neurones were identified by a retrograde tracing method with dextran‐tetramethylrhodamine‐lysine. The injection of the tracer into the chorda‐lingual nerve labelled the neurones innervating the submandibular ganglia and those innervating the intra‐lingual ganglia, while the injection into the tip of the tongue labelled the latter group of neurones. Firing characteristics were investigated mainly in the neurones of 6–8 days postnatal rats. In response to an injection of long depolarizing current pulses at hyperpolarized membrane potentials (< −80 mV) under a current clamp, the neurones labelled from the nerve displayed a train of action potentials with either a long silent period preceding the first spike (late spiking pattern) or a long silent period interposed between the first and second spikes (interrupted spiking pattern). The neurones labelled from the tongue invariably displayed the interrupted spiking pattern. Under a voltage clamp, among the neurones from 6–8 days postnatal rats, those labelled from the nerve expressed either a fast or a slow transient outward current (A‐current), while those labelled from the tongue invariably showed a slow transient outward current. Both the fast and slow A‐currents were largely depressed by 1 mm 4‐aminopyridine. Similar fast and slow A‐currents were observed in the neurones of rats aged 14–15 days. Both the time to peak and decay time constant of these A‐currents were accelerated, suggesting a developmental trend of maturation in the activation and inactivation kinetics between 6 and 15 days postnatal. Based on the differences in the firing pattern and outward current, the superior salivatory neurones can be separated into two distinct types. We discuss the functional aspects of these two types of neurones with reference to their target organs.

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An electrophysiological study of the postnatal development of the autonomic innervation of the rat submandibular salivary gland

Cited by 36 publications

References 16 publications

Salivary Glands: A Paradigm for Diversity of Gland Development

Salivary Glands: A Paradigm for Diversity of Gland Development

Differences in Morphology and Neuropeptide Immunoreactivity of Superior Cervical Ganglion Neurons that Innervate the Major Salivary Glands in Rats.

Two types of parasympathetic preganglionic neurones in the superior salivatory nucleus characterized electrophysiologically in slice preparations of neonatal rats

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