An elevated cadaverine content in the brain of dormant mice

Doležalová, Hana; Stepita-Klauco, Matej; Fairweather, Robert B.

doi:10.1016/0006-8993(74)90813-0

Cited by 15 publications

(3 citation statements)

References 20 publications

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“…Cadaverine (1 ,Sdiaminopentane) is a naturally occurring constituent of mouse brain and blood (Dolezalova et al, 1974). Although cadaverine is one of the best known substrates for diamine oxidase (EC 1.4.3.6), little has been reported on the fate of cadaverine by this pathway beyond the initial formation of the deamination product l-piperideine (Tabor, 1951).…”

mentioning

confidence: 99%

Biosynthesis of 5‐Aminopentanoic Acid and 2‐Piperidone from Cadaverine and 1‐Piperideine in Mouse

Callery

Geelhaar

1984

Journal of Neurochemistry

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1-Piperideine, 5-aminopentanoic acid, and its lactam, 2-piperidone, were identified as metabolites of cadaverine in 10,000 g mouse liver supernatants to which diamine oxidase had been added. Both metabolites were also found when the cadaverine metabolite 1-piperideine was incubated with the preparation which suggested that 1-piperideine is an intermediate in the formation of 5-aminopentanoic acid and 2-piperidone. Identification of the metabolites was based on gas chromatography-mass spectrometric analysis in comparison to authentic standards. Mouse brain homogenates converted 1-piperideine to 5-aminopentanoic acid. The results suggest that the metabolic fate of cadaverine may provide precursors of pharmacologically active analogues of GABA.

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confidence: 99%

Biosynthesis of 5‐Aminopentanoic Acid and 2‐Piperidone from Cadaverine and 1‐Piperideine in Mouse

Callery

Geelhaar

1984

Journal of Neurochemistry

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“…The aliphatic diamines, PUT and CAD, occur in the mammalian brain (1)(2)(3)(4), and PUT is known to be the direct precursor of spermidine (5), and associated with cell growth or proliferation (6). The existence of a pathway from PUT to y -aminobutyric acid (GABA) in the mammalian brain has been reported (7)(8)(9)(10).…”

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confidence: 99%

“…Moreover, part of the endogenous PUT is localized within nerve endings (11), and the active uptake system for ornithine, a direct precursor of PUT, into nerve endings has also been reported (12). A significant increase in CAD content in both the brain and the blood of dormant mice has been reported (2), and a high concentration of monoacyl-CAD was found in the blood of schizophrenic patients (13,14).…”

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confidence: 99%

Effects of intracerebroventricular administration of aliphatic diamines on ingestive behavior in the rat.

Kohno¹,

Sakurada²,

Kisara³

1981

Jpn.J.Pharmacol

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Abstract-We examined the pharmacological effects of intracerebroven tricularly administered aliphatic diamines on ingestive behavior in male rats adapted to a 4 hr per day feeding and drinking schedule. 1,2 Ethanediamine (ETD), 1,3-propanediamine (PRD), 1,4-butanediamine (putrescine, PUT), 1,5-pentanediamine (cadaverine, CAD) and 1,6 hexanediamine (HED) suppressed feeding and drinking behavior in a dose dependent manner, but not unless a relatively high dose (over 80 /1g) was given. The approximate anorectic potency was HED>CAD=PUT> ETD>PRD. A sedation was also produced in fairly good parallel to these alterations in feeding and drinking behavior. Thus, there appears to be a relationship between the length of the carbon chain and the potency of the pharmacological action, and these inhibitory effects on feeding and drinking behavior are probably not due to a specific action on the regulatory system for ingestive behavior, but rather to a nonspecific action.

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An Assay for Schizophrenia: Mass Spectrometry Determination of Two Cadaverine Metabolites

Doležalová

Stepita-Klauco

Velde

et al. 1979

Recent Developments in Mass Spectrometry in Biochemistry and Medicine

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An elevated cadaverine content in the brain of dormant mice

Cited by 15 publications

References 20 publications

Biosynthesis of 5‐Aminopentanoic Acid and 2‐Piperidone from Cadaverine and 1‐Piperideine in Mouse

Biosynthesis of 5‐Aminopentanoic Acid and 2‐Piperidone from Cadaverine and 1‐Piperideine in Mouse

Effects of intracerebroventricular administration of aliphatic diamines on ingestive behavior in the rat.

An Assay for Schizophrenia: Mass Spectrometry Determination of Two Cadaverine Metabolites

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