An “elite hacker”

Boudreau, Aaron; Veer, Laura J. van ’t; Bissell, Mina J.

doi:10.4161/cam.20880

Cited by 38 publications

(23 citation statements)

References 202 publications

(227 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of most solid tumors is intimately linked to external cues provided by the microenvironment (1). Based mainly on associative studies in human cancers and tumor transplant models, a family of chemotactic proteins termed chemokines has emerged as important molecular regulators of carcinogenesis by shaping the tumor milieu.…”

Section: Introductionmentioning

confidence: 99%

CX3CL1 Promotes Breast Cancer via Transactivation of the EGF Pathway

et al. 2013

View full text Add to dashboard Cite

Chemokines are relevant molecules in shaping the tumor microenvironment, although their contributions to tumorigenesis are not fully understood. We studied the influence of the chemokine CX3CL1/fractalkine in de novo breast cancer formation using HER2/neu transgenic mice. CX3CL1 expression was downmodulated in HER2/neu tumors, yet, paradoxically, adenovirus-mediated CX3CL1 expression in the tumor milieu enhanced mammary tumor numbers in a dose-dependent manner. Increased tumor multiplicity was not a consequence of CX3CL1-induced metastatic dissemination of the primary tumor, although CX3CL1 induced epithelial-to-mesenchymal transition in breast cancer cells in vitro. Instead, CX3CL1 triggered cell proliferation by induction of ErbB receptors through the proteolytic shedding of an ErbB ligand. This effect was important insofar as mammary tumorigenesis was delayed and tumor multiplicity was reduced by genetic deletion of CX3CL1 in HER2/neu mice, but not in polyoma middle T-antigen oncomice. Our findings support the conclusion that CX3CL1 acts as a positive modifier of breast cancer in concert with ErbB receptors.

show abstract

Section: Introductionmentioning

confidence: 99%

CX3CL1 Promotes Breast Cancer via Transactivation of the EGF Pathway

et al. 2013

View full text Add to dashboard Cite

show abstract

“…is mirrored, hijacked and exaggerated during breast cancer progression. 5 Using the same model, Conklin et al describe how increased tumor cellularity and deposition of ECM molecules fosters mammographic density. 6 They further discuss the importance of force-dependent matrix remodeling by CAFs (in particular collagen alignment) during tumor invasion and how this topographical remodeling correlates with tumor invasiveness.…”

Section: Tumor Microenvironment: How It Is Being "Hacked" By the Tumormentioning

confidence: 99%

“…2 Boudreau et al suggest that similarities are also shared for example by normal branching morphogenesis and breast tumor invasion. 5 Indeed, in both scenarios, the ECM is proteolyzed, aligned and remodeled as the epithelium invades the stroma. Normal and tumor-associated ECM nevertheless differ in terms of their mechano-topographical properties.…”

Section: The Tumor Microenvironment: Stromal Cells and Extracellular mentioning

confidence: 99%

“…Furthermore, Boudreau et al discuss the evidence that the multigene signatures currently used to model cancer heterogeneity and clinical outcome largely reflect signaling from a heterogeneous microenvironment and propose that this could be exploited therapeutically. 5 The fact that scientists increasingly became aware of the importance of microenvironment in tumor progression drastically changed the way it is being perceived and studied and opened a breach for successful therapeutic targeting. As can be judged from this special focus, scientists have grasped the importance of this emerging phenomenon and actively participate to the dissection of its underlying mechanisms.…”

Section: Tumor Microenvironment and Therapy: Ally Or Foe?mentioning

confidence: 99%

See 1 more Smart Citation

Tumor microenvironment indoctrination

Goetz

2012

Cell Adhesion & Migration

View full text Add to dashboard Cite

“…The tumor microenvironment is composed of various cell types with numerous studies showing they each play distinct and important roles in tumorigenesis 1,2 . These include, but are not limited to, infiltrating immune cells, stromal cells, endothelial cells and tumor cells 3 .…”

Section: Introductionmentioning

confidence: 99%