“…The host organism, namely Artemia , responds in a different manner to each probiotic, with the increased antioxidant enzyme activity suggesting an immunostimulatory effect of probiotics. The production of different active substances by each probiotic, namely lysozyme [ 41 , 42 ], bacteriocins [39] and selenium nanoparticles [ 44 , 88 , 89 ] by B. subtilis, organic acids and bacteriocins including nisin by L. lactis [41] and organic acids, plantaricin, hydrogen peroxide, phenolic compounds, and surfactants by L. plantarum [90] might contribute to this variable effect among the probiotics employed. In fact, the addition of lysozyme significantly decreased the MDA content, and increased (SOD), activity, improving gur health in piglets [91] , plantaricin presented a synergistic action with lactic acid against A. hydrophila [92] and nisin was reported to boost growth performance and increases infection clearance rate in humans by upregulating innate and acquired immune responses [93] .…”