An embryonic tumour of the liver containing striated muscle

Liver tumour of mixed type

“…This tumour had many features in common with a liver tumour described by Sheehan (1930) which was found in a 6-year-old girl and consisted of a number of cysts, lined by bile-duct epithelium, and embryonic cells. Some of the latter had differentiated into striated muscle.…”

Liver tumours in infancy and childhood

“…The nomenclature of the classifications is inconstant. Morphologically similar tumours have been called carcinoma (Wilbur, Wood and Willet, 1944;Fish and McGary, 1966); malignant adenoma (McRae, 1935); embryonic mixed tumour (Allison and Willis, 1956); embryonic tumour (Sheehan, 1930); mixed tumour (Milman and Grayzel, 1951), and adenoma (Shaw, 1923 ;Wilens, 1938). Macnab et al (1952) describe two groups of liver tumours; hepatoblastoma in infants and carcinoma in older children.…”

Tumors of the Striated Muscle Cell Lineage: Hepatobiliary Rhabdomyosarcoma and Rhabdomyoma

“…Non-necrotic tumors have an intact surface toward the biliary lumen. Already Sheehan (1930), in his report of a large intrahepatic HBRMS, emphasized that "the mucous columnar epithelium of the included cysts and the bile ducts remained intact and healthy. Thus in the extension down the common bile-duct the large mass of tumour cells had spread underneath the epithelium which it had raised undamaged on its surface."…”

“…Only in two reports there is evidence of an alveolar component. In a pediatric hepatic rhabdomyosarcoma with striated tumor cells and associated with mucin-producing cysts reported in 1930 (Sheehan 1930), one figure of the publication depicts what seem to be alveolar rhabdomyosarcoma. The other patient with an alveolar hepatic RMS was an adult male (68 years) with a tumor in the right liver lobe (Shibata et al 1987).…”

“…The lesion has first been described in 1875 (Wilks and Moxon 1875) and has later also been described as embryonic tumor with striated muscle (Sheehan 1930), a malignant mixed tumor of the choledochal duct (Goeters 1941), and a cystic liver tumor of the mixed type (Williams 1953). The case of Sheehan (1930), a 6-year-old girl, was described in great detail, and the author already pointed out that this type of tumor may present in the form of intrahepatic cysts representing dilated bile ducts obstructed by the intraluminally growing tumor. The lesion was further specified by Willis (1962).…”