An Emerging Method to Assess Tear Film Spread and Dynamics as Possible Tear Film Homeostasis Markers

García‐Marqués, José Vicente; Talens‐Estarelles, Cristian; Martínez-Albert, Noelia; García‐Lázaro, Santiago; Cerviño, Alejandro

doi:10.1080/02713683.2021.1887270

Cited by 5 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies started to focus on the tear breakup process in some ocular surface diseases using keratograph. 15,16,28 Although keratograph is considered as a noninvasive method to better reflect the tear breakup process, it shows poor diagnostic ability in identifying eyes with pterygium owing to its irregular surface appearance. This study chose 2% fluorescein instillation (1μL) to observe the tear breakup process, which produced comparable results compared with noninvasive methods, and maximum brightness occurred almost immediately after instillation and lasted approximately 2minutes.…”

Section: Discussionmentioning

confidence: 99%

“…The tear distribution and dynamics of pterygium could be fully inconsistent with common dry eye. Several studies started to focus on the tear breakup process in some ocular surface diseases using keratograph 15,16,28 . Although keratograph is considered as a noninvasive method to better reflect the tear breakup process, it shows poor diagnostic ability in identifying eyes with pterygium owing to its irregular surface appearance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Unique Properties of Tear Film Break-up Process in Patients with Nasal Unilateral Pterygium

Chang,

Lin,

Kang

et al. 2023

Optom Vis Sci

View full text Add to dashboard Cite

Significance This study found that the unique properties of tear film break-up process in eyes with pterygium, which, combined with ocular surface parameters, further revealed specific dynamic mechanism. It suggested the thickness of pterygium was especially valuable in deciding the necessity of surgical management. Purpose To explore the dynamics mechanism of tear film instability in eyes with pterygium. Methods A paired-eye controlled cross-sectional study. 78 patients with nasal pterygium were enrolled. Fluorescein tear film breakup was observed. Several key parameters related to tear film quality were defined and analyzed, including total break-up area (mathematically derived from pixel size using MATLAB), break-up velocity, fluorescein break-up time, break-up location and pattern, tear meniscus height (TMH), score of fluorescein corneal staining (SCSF) and meiboscore. Results With comparable TMH, SCSF and meiboscore between paired eyes (P > .05), eyes with pterygium had shorter break-up time, larger break-up area and faster break-up velocity (P < .05). In eyes with pterygium, a positive correlation between meiboscore and pterygium parameters including length, thickness and size were observed (P < .001). As the thickness increased, difference of break-up time and area between paired eyes increased (P = .02 and .046). Eyes with pterygium had more fixed inferonasal break-up location and often presented as dimple break (60.3%) while random break was the most common in contralateral normal eyes (61.5%). A unique break-up pattern named pterygium-induced local dimple break was found. It displayed as irregular but vertical line-like shape appearing after lipid layer spreading, which adjacent to lower margin of pterygium and presented unique properties including inferonasal break-up location, local break-up area, shorten break-up time and faster break-up velocity. Conclusions Eyes with pterygium showed a unique tear film break-up process and novel break-up pattern named pterygium-induced local dimple break. Dynamic mechanism played a significant role in tear film instability of eyes with pterygium rather than aqueous-deficiency and increased-evaporation.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Unique Properties of Tear Film Break-up Process in Patients with Nasal Unilateral Pterygium

Chang,

Lin,

Kang

et al. 2023

Optom Vis Sci

View full text Add to dashboard Cite

show abstract

“…Blinking is a complex phenomenon that has not been studied in patients with tarsorrhaphy to the best of our knowledge; however, it is known about the importance of this phenomena for the ocular surface homeostasis, in fact, eyelid movements disorders are behind many cases of corneal impairment and new research in tear film homeostasis point to the blinking and post-blinking tear dynamics as an important parameter. 22,23 The main complications of PTCF described in the literature include damage to the lacrimal canaliculus, unaesthetic scarring, upper and lower lid retraction, limited peripheral vision, flap rupture, trichiasis, pyogenic granuloma, keloid scarring, inadequate corneal protection and cosmetic impact for the patient. 4,21 However, these complications are referred mainly to the PTCF used in eyelid reconstructions, which is usually much bigger in size, we consider that a refined surgical technique can minimize these complications.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pillar tarsoconjunctival flap: An alternative approach for the management of refractory corneal ulcer

Zamorano‐Martin

Rocha‐de‐Lossada

Rodríguez‐Calvo‐de‐Mora

et al. 2022

European Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose To report the effectiveness of the surgical procedure of the tarsoconjunctival flap (FTC) in patients with severe ocular surface impairment refractory to previous conventional treatments. Methods A retrospective, noncomparative, consecutive case series. Results Pillar tarsoconjunctival flap (PTCF) was performed in eight eyes of eight patients. Three patients had neurotrophic corneal ulcer (NCU), three had exposure keratopathy and two had corneal melting. Seven of them had satisfactory postoperative results, showing total corneal re-epithelialization that lasted throughout the postoperative follow-up (mean 10.33 ± 2.65 months [SD], range 6 to 12 months). Mean time for the re-epithelization was 11.28 ± 8.97 days [SD] (range 4 to 30 days). Conclusion This study suggest PTCF is a valid alternative to tarsorrhaphy in cases of persistent epithelial defect (PED) or NCU resistant to conventional treatments. Notwithstanding, prospective comparative trials comparing PTFC with conventional and/or novel therapies in PED or NCU are needed to corroborate these findings.

show abstract

“…The masked technicians interpreted the examination procedure for the subject before each tear film test. After completing a dry eye questionnaire with Ocular Surface Disease Index (OSDI) [24], each subject received a series of ocular surface examinations with the K5M, including TMH [25][26][27][28][29], TFV [15,16,30,31], ocular surface redness [26,28,29,32], NIKBUT [25][26][27][28][29], and meibography [27,28,33]. Finally, each subject received cobalt blue light illuminated corneal photography after fluorescence dye staining to determine the corneal epitheliopathy [28,29,34].…”

Section: Assessment Protocolmentioning

confidence: 99%

Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease

Lai

Chen²,

Fang

et al. 2023

Life

View full text Add to dashboard Cite

This study aimed to compare tear film viscosity (TFV) in Sjögren and non-Sjögren dry eye diseases (DEDs). This was a cross-sectional observational study. A total of 68 DED patients were enrolled, including 32 patients with Sjögren syndrome (SS) and 36 without SS. TFV was assessed by a tear film analyzer and determined by the momentary moving speed (MMS; MMS (t) = α × t−β, t = time (s)) with its power-law fitting-derived parameters (α and β). Among the four indices of TFV (MMS (0.1 s), MMS (2.0 s), α, and β), the SS-DED patients had significantly lower MMS (0.1 s) (p = 2.01 × 10−5), α (p = 0.0375), and β (p = 0.0076). The SS-DED group also had significantly higher OSDI, lower central and nasal tear meniscus height (TMH), and higher OSS. MMS (0.1 s) was significantly correlated with nasal TMH and OSS (ρ = 0.2520, p = 0.0381 in nasal TMH; ρ = −0.3487, p = 0.0036 in OSS). Index β was not correlated with any non-TFV tests. In conclusion, MMS (0.1 s), α, and β are promising TFV indices in distinguishing SS-DED from non-SS-DED patients early. Among these TFV indices, lower MMS is the best alternative clue for detecting SS-DED.

show abstract

An Emerging Method to Assess Tear Film Spread and Dynamics as Possible Tear Film Homeostasis Markers

Cited by 5 publications

References 40 publications

The Unique Properties of Tear Film Break-up Process in Patients with Nasal Unilateral Pterygium

The Unique Properties of Tear Film Break-up Process in Patients with Nasal Unilateral Pterygium

Pillar tarsoconjunctival flap: An alternative approach for the management of refractory corneal ulcer

Comparing Tear Film Viscosity between Sjögren and Non-Sjögren Dry Eye Disease

Contact Info

Product

Resources

About