An emerging platform for drug delivery: Aerogel based systems

Synthesis and biomedical applications of aerogels: Possibilities and challenges

“…The mold should be chosen in such a way that it will not have any reaction with the sol, prior and after the gelation, and allow facile de-molding of the wet gel. In this regard, Teflon or propylene molds, with regular and parallel sides, are chosen in most of the cases for allowing easy release of wet gels with minimum surface irregularities [17].…”

“…Novel formulations of drug delivery systems are being intensively studied for conditions [17,18,199].…”

“…The loading of the drug in the aerogels can be carried out either during the sol-gel process itself, during the solvent exchange of the gels or by supercritical impregnation of aerogel depending on the drug stability and affinity for solvents (water, organic solvent, scCO 2 ) and for the aerogel matrix [17,18,30,172,200]. The release profile of the drug loaded into the aerogels will be dependent on the nature of the aerogel [171] and can be modified by using different methods like multi-membrane hydrogel formation, preparation of hybrid aerogels, surface derivatization of aerogels or aerogel post-coating [200][201][202][203].…”

Aerogels as drug delivery systems: In vitro and in vivo evaluations

“…There are also different ways of increasing drug bioavailability, for example: delivery systems based on lipids, soft-emulsifying systems, etc. One of the most perspective ways to increase release rate and the bioavailability rate is the impregnation of the active pharmaceutical ingredient (API) into the aerogel [1][2][3].…”

Cellulose Nanofibril Based-Aerogel Microreactors: A High Efficiency and Easy Recoverable W/O/W Membrane Separation System

“…Nano cellulose based aerogel promises not only a very low density and high porosity which is typical in aerogels, but also a high strength and ductility compared with inorganic or polymeric aerogels1. Due to these advantages, the cellulose nanofibril (CNF) aerogel has received much attention in many applications, especially as a carrier in selective separation or as scaffold material and carriers for drug delivery in medicine23. Zhang et al .…”