An emerging technique of medicated chewing gum in drug delivery system: a review

Khatiwara, Deepika; Ranabhat, Priyanka; Paul, Moumita; Bagchi, Amiya Kumar

doi:10.18231/j.joapr.2021.1.8

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Among the routes of administration, the oral types are attractive, mostly because of their comfortable appliances. As a result, approaches based on chewable carriers, such as drug-loaded gums and tablets, show some promise for many oral, esophageal, and GI-related diseases [ 8 , 9 ]. Considering its unique characteristics, oral-based chewy delivery is highlighted as a promising candidate.…”

Section: Introductionmentioning

confidence: 99%

“…Considering its unique characteristics, oral-based chewy delivery is highlighted as a promising candidate. Rapid onset of action, facile administration, low side effects, and appropriate local impact on oral diseases are all major factors contributing to this salience [ 9 – 11 ]. In this study, we discussed the characteristics of oral conditions for the effect of medications and the application of chewing gums in drug delivery for oral health.…”

Section: Introductionmentioning

confidence: 99%

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Chewing Gums as a Drug Delivery Approach for Oral Health

Banakar

Moayedi

Shamsoddin³

et al. 2022

International Journal of Dentistry

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Background. Drug delivery approaches with the shortest therapeutic period and the lowest side effects have always been considered a sublime target in the medical sciences. Among many delivery methods, chewing gum could be perceived as a promising drug carrier that can carry several types of drugs for oral health. These drug carriers could represent optimal therapeutic time and lower side effects due to their sustained release capability and lower required thresholds for the drug compared with other delivery approaches. The convenient use in the oral cavity’s local environment and the ability to locally carry multiple drugs are considered the main advantages of this delivery approach. Aim. This review aimed to explore chewing gum as a promising drug carrier that can carry several types of drugs for oral health. Materials and Methods. Articles were searched for on PubMed, ISI, SCOPUS, Google Patents, the Royal Society of Chemistry website, and electronic databases using MESH terms and the following keywords: (“Gum” OR “Chewing gum”) and (“Drug delivery OR Drug delivery systems”) in the English language. No time limit was applied, and all documents as of August 30th, 2020 were retrieved. Results. Gum-drug interactions, mechanisms of release, and formulations of the drugs might all play a role in this versatile delivery method. Accordingly, chewing gum-based carriers may be presented as a plausible candidate for drug delivery in oral diseases. Conclusion. Gum-driven drugs could be introduced as promising candidates for treating oral diseases due to their ability to deliver the proper local dosages of active ingredients, short contact time, biocompatibility, and biodegradable chemical structures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chewing Gums as a Drug Delivery Approach for Oral Health

Banakar

Moayedi

Shamsoddin³

et al. 2022

International Journal of Dentistry

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“…The medicine, which has been blended into the base of the gum, is released into the saliva, absorbed through the oral mucosa, or eaten, and finally enters the stomach for gastrointestinal absorption. According to numerous research, this type of dosage form makes people more alert, relaxed, and focused [9]. This type of dosage form is a suitable candidate for local treatment of oral diseases.…”

Section: Introductionmentioning

confidence: 99%

Medicated chewing gum: as a new generation drug carrier/dosage form

Jain,

Das,

Khatiwara

et al. 2022

UJPSR

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The study and development of oral medication delivery systems has seen advancements in both medicine and technology in recent years. Due to greater patient compliance, not only in geriatric and paediatric patients but also in the general population, medicated chewing gum has attracted attention on a global scale throughout the year. This distribution mechanism for drugs since it is easy to use and works without water, self-medication. The invention of medicated chewing gums (MCGs) heralds a revolutionary new era in oral transportable medication. It is described as a solid single-dose formulation with a base of gum that must be effortlessly chewed for a set amount of time. It may also have more than one active component. Additionally, because the official Pharmacopoeias only suggest a small number of tests, there aren't many assessment parameters available

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Medicated Chewing Gums: A Revolution in Self-Medication And Drug Delivery

Sontakke

2024

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Medicated chewing gums (MCGs) are characterized as ‘solid single-dose preparations with a base consistingmainly of gum that is intended to be chewed but not to be swallowed, providing a slow steady release of themedicine contained’. The European Pharmacopoeias (Ph. Eur) along with the U.S. Pharmacopoeias (USP)formally acknowledged medicated chewing gums as an acceptable method for medication administration.MCGs have become a new and exciting method in the realm of oral drug delivery. The potential benefits ofchewing gums over conventional drug delivery method are examined in this review paper. Notable benefitsinclude the circumvention of hepatic first-pass effect, patient compliance, local and systemic action, andvarious other advantages that make them an exciting alternative in pharmaceutical research. Thiscomprehensive review paper covers all essential aspects related to medicated chewing gums, including theircomposition, advantages, disadvantages, methods of preparation, and future trends. It also underscores thepotential of medicated chewing gums as a useful substitute to buccal medication delivery and emphasizestheneed for further exploration and research in this field.

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An emerging technique of medicated chewing gum in drug delivery system: a review

Cited by 3 publications

References 14 publications

Chewing Gums as a Drug Delivery Approach for Oral Health

Chewing Gums as a Drug Delivery Approach for Oral Health

Medicated chewing gum: as a new generation drug carrier/dosage form

Medicated Chewing Gums: A Revolution in Self-Medication And Drug Delivery

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