The purpose of the study was to assess the relationship between trauma-related sleep disturbance and physical health symptoms in treatment-seeking female rape victims. A total of 167 participants were assessed for PTSD symptoms, depression, sleep disturbance, and frequency of self-reported health symptoms. Results demonstrated that trauma-related sleep disturbance predicted unique variance in physical health symptoms after other PTSD and depression symptoms were controlled. The findings suggest that trauma-related sleep disturbance is one potential factor contributing to physical health symptoms in rape victims with PTSD.Violence against women yields a variety of deleterious effects, both direct and indirect, on objective and subjective indices of physical health (Resnick et al., 1997). In addition to psychological reactions to trauma such as posttraumatic stress disorder (PTSD) and depression, women who have experienced criminal victimization report a variety of physical symptoms that range across bodily systems, including cardiovascular, gynecological, respiratory, musculoskeletal, and dermatological systems (Kimerling and Calhoun, 1994;Koss et al., 1991).Several studies have demonstrated that PTSD is a mediating factor in the relationship between trauma exposure and reports of elevated health symptoms in women Wolfe et al., 1994). Researchers have proposed multiple biological mechanisms to explain the impact of PTSD on health (Friedman and Schnurr, 1995). Among these proposed mechanisms is the chronic autonomic hyperarousal (Koss and Heslet, 1992;McFarlane et al., 1994) and sleep disturbance associated with PTSD (Friedman and Schnurr, 1995). The hypothesized link between autonomic arousal and physical health was bolstered by the recent finding that the hyperarousal symptom cluster of PTSD was the strongest of the PTSD symptom subclusters in predicting both total health symptoms and global health perception in a sample of women veterans .Given the observed relationships between PTSD, particularly hyperarousal symptoms, and health outcomes, and the potential impact of biological alterations associated with a PTSD diagnosis, we hypothesized that sleep disturbance associated with psychological reactions to trauma may be an important predictor of health symptoms. Sleep disturbance has been associated with a variety of negative health outcomes, including immune system alterations, cardiovascular incidents, and general health symptoms (Kales et al., 1984;Newman et al., 1997). Further, in a study investigating the aftermath of Hurricane Andrew, self-reported sleep disturbance mediated between PTSD symptoms and an index of immune functioning (NKCC levels;Ironson et al., 1997 Recent research suggests that, in addition to PTSD symptoms, depressive symptoms are important in the prediction of self-reported health symptoms after trauma Wolfe et al., 1999). A diagnosis of depression independent of trauma exposure has been linked to poorer reported health and immune system alterations (Miller et al., 1999;Schulberg ...