Effect of process variables on overall (U) and fluid-to-particle (h fp ) heat-transfer coefficients in canned particulates suspended in Newtonian fluids (glycerin solutions at concentrations of 80-100%) undergoing free axial rotation was evaluated in a pilot-scale rotary autoclave. Six influencing factors affecting U and h fp were selected using L 16 Taguchi model for detailed evaluation. With the significant factors identified, a response surface methodology and two full-factorial experimental designs of experiments were used to relate U and h fp to the various process and product variables in each mode of rotation (fixed and free axial modes). The analysis of variance showed that the rotational speed, glycerin concentration (contributing to fluid viscosity), retort temperature, particle material (contributing to particle density), particle concentration and particle size were significant factors (p<0.05) for h fp and U. Headspace was not significant in the range of 5 to 10 mm studied. With an increase in rotational speed, particle density, and retort temperature, there was an increase in the associated h fp and U values; however, increasing the glycerin concentration resulted in the opposite. An increase in particle concentration showed an initial increasing trend in h fp and U values which, subsequently, decreased with a further increase in particle concentration. T tests revealed that both U and h fp were significantly higher ( p<0.01) in the free axial mode as compared to the fixed axial mode.